Premature ovarian insufficiency (POI) is the loss of normal ovarian function before the age of
40 years, a condition that affects approximately 1% of women under 40 years old and 0.1 …

Primary ovarian insufficiency (POI) is determined by exhaustion of follicles in the ovaries,
which leads to infertility before the age of 40 years. It is characterized by a strong familial …

Background The loss of ovarian function in women, referred to as premature ovarian
insufficiency (POI), is associated with a series of concomitant diseases. POI is genetically …

Bone morphogenetic proteins (BMPs) are a group of multifunctional growth factors that
belong to the transforming growth factor-β (TGF-β) superfamily of proteins. Originally …

Ovarian infertility and subfertility presenting with premature ovarian insufficiency (POI) and
diminished ovarian reserve are major issues facing the developed world due to the trend of …

Anti-Müllerian hormone (AMH) is a member of the TGF-β family produced essentially by the
supporting somatic cells of the testis. Initially known for its inhibiting role upon the …

The chromosomal sex of the embryo is established at fertilization. However, 6 weeks elapse
in humans before the first signs of sex differentiation are noticed. Sex differentiation involves …

Introduction Ovarian aging has steadily grown to be a significant health issue for women as
a result of the increase in average life expectancy and the postponement of reproductive …

Context A genetic etiology likely accounts for the majority of unexplained primary ovarian
insufficiency (POI). Objective We hypothesized that heterozygous rare variants and variants …

Acromesomelic dysplasia Grebe type (AMD Grebe type) is an autosomal recessive trait
characterized by short stature, shortened limbs and malformations of the hands and feet. It is …