[HTML][HTML] Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity
E Guiot, K Carayon, O Delelis, F Simon, P Tauc… - Journal of Biological …, 2006 - ASBMB
The 3′-processing of the extremities of viral DNA is the first of two reactions catalyzed by
HIV-1 integrase (IN). High order IN multimers (tetramers) are required for complete …
HIV-1 integrase (IN). High order IN multimers (tetramers) are required for complete …
Oligonucleotide-based assays for integrase activity
G Merkel, MD Andrake, J Ramcharan, AM Skalka - Methods, 2009 - Elsevier
Oligonucleotide assays have been invaluable for elucidation of the molecular mechanisms
of retroviral integrases. A suite of rapid and sensitive fluorescence assays to measure the …
of retroviral integrases. A suite of rapid and sensitive fluorescence assays to measure the …
Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration
KK Pandey, S Sinha, DP Grandgenett - Journal of virology, 2007 - Am Soc Microbiol
Human transcriptional coactivator p75/lens epithelium-derived growth factor (LEDGF) binds
human immunodeficiency virus type 1 (HIV-1) integrase (IN). We studied the effects of …
human immunodeficiency virus type 1 (HIV-1) integrase (IN). We studied the effects of …
Molecular interactions between HIV-1 integrase and the two viral DNA ends within the synaptic complex that mediates concerted integration
A macromolecular nucleoprotein complex in retrovirus-infected cells, termed the
preintegration complex, is responsible for the concerted integration of linear viral DNA …
preintegration complex, is responsible for the concerted integration of linear viral DNA …
Inhibition of human immunodeficiency virus type 1 concerted integration by strand transfer inhibitors which recognize a transient structural intermediate
Human immunodeficiency virus type 1 (HIV-1) integrase (IN) inserts the viral DNA genome
into host chromosomes. Here, by native agarose gel electrophoresis, using recombinant IN …
into host chromosomes. Here, by native agarose gel electrophoresis, using recombinant IN …
Small-angle X-ray characterization of the nucleoprotein complexes resulting from DNA-induced oligomerization of HIV-1 integrase
S Baranova, FV Tuzikov, OD Zakharova… - Nucleic acids …, 2007 - academic.oup.com
Abstract HIV-1 integrase (IN) catalyses integration of a DNA copy of the viral genome into
the host genome. Specific interactions between retroviral IN and long terminal repeats (LTR) …
the host genome. Specific interactions between retroviral IN and long terminal repeats (LTR) …
A new fluorometric assay for the study of DNA-binding and 3′-processing activities of retroviral integrases and its use for screening of HIV-1 integrase inhibitors
A Anisenko, J Agapkina, T Zatsepin, D Yanvarev… - Biochimie, 2012 - Elsevier
Fluorometry using a substrate DNA labeled with a single fluorophore (6-carboxyfluorescein)
at the 3′-end of the processed strand was shown to be a useful tool for monitoring DNA …
at the 3′-end of the processed strand was shown to be a useful tool for monitoring DNA …
[HTML][HTML] Differential assembly of Rous sarcoma virus tetrameric and octameric intasomes is regulated by the C-terminal domain and tail region of integrase
Retrovirus integrase (IN) catalyzes the concerted integration of linear viral DNA ends into
chromosomes. The atomic structures of five different retrovirus IN–DNA complexes, termed …
chromosomes. The atomic structures of five different retrovirus IN–DNA complexes, termed …
[HTML][HTML] Rous sarcoma virus synaptic complex capable of concerted integration is kinetically trapped by human immunodeficiency virus integrase strand transfer …
We determined conditions to produce milligram quantities of the soluble Rous sarcoma virus
(RSV) synaptic complex that is kinetically trapped by HIV strand transfer inhibitors (STIs) …
(RSV) synaptic complex that is kinetically trapped by HIV strand transfer inhibitors (STIs) …
Catalytic antibodies from HIV‐infected patients specifically hydrolyzing viral integrase suppress the enzyme catalytic activities
ES Odintsova, SV Baranova, VN Buneva… - Journal of Molecular …, 2011 - Wiley Online Library
Human immunodeficiency virus type 1 integrase (IN) catalyzes integration of a DNA copy of
the viral genome into the host genome. It was shown previously that IN preincubation with …
the viral genome into the host genome. It was shown previously that IN preincubation with …