An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
Epigenetic basis of mental illness
Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …
neural circuit structure and function as well as likely abnormalities in glial cells. While …
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment
There is mounting evidence that seemingly diverse psychiatric disorders share genetic
etiology, but the biological substrates mediating this overlap are not well characterized. Here …
etiology, but the biological substrates mediating this overlap are not well characterized. Here …
Hidden wounds? Inflammatory links between childhood trauma and psychopathology
A Danese, JR Baldwin - Annual review of psychology, 2017 - annualreviews.org
Childhood trauma is a key risk factor for psychopathology. However, little is known about
how exposure to childhood trauma is translated into biological risk for psychopathology …
how exposure to childhood trauma is translated into biological risk for psychopathology …
Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk
INTRODUCTION Chromosomal conformations, topologically associated chromatin domains
(TADs) assembling in nested fashion across hundreds of kilobases, and other “three …
(TADs) assembling in nested fashion across hundreds of kilobases, and other “three …
Computational psychiatry: towards a mathematically informed understanding of mental illness
Computational Psychiatry aims to describe the relationship between the brain's
neurobiology, its environment and mental symptoms in computational terms. In so doing, it …
neurobiology, its environment and mental symptoms in computational terms. In so doing, it …
The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability
By performing a meta-analysis of rare coding variants in whole-exome sequences from
4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and …
4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and …
The emerging tale of microglia in psychiatric disorders
As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …
response and play an increasingly important role in maintaining homeostatic brain functions …
Synergistic effects of common schizophrenia risk variants
The mechanisms by which common risk variants of small effect interact to contribute to
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …