Characterized by impaired mucus transport and subsequent enhanced colonization of
bacteria, pulmonary infection causes major morbidity and mortality in patients with cystic …

Pseudomonas aeruginosa biofilm infections in the cystic fibrosis (CF) lung are highly
resistant to current antimicrobial treatments and are associated with increased mortality …

Background Cystic fibrosis is a genetic disorder in which abnormal mucus in the lungs is
associated with susceptibility to persistent infection. Pulmonary exacerbations are when …

Pseudomonas aeruginosa is a common opportunistic pathogen that causes acute
nosocomial necrotizing pneumonia and is the predominant source of chronic lung infections …

Whenever Pseudomonas aeruginosa is cultured from cystic fibrosis (CF) patient airways, the
primary goal is eradication by antibiotic therapy. Success is defined by≥ 6 months of …

Antimicrobial resistance poses a significant threat to modern healthcare as it limits treatment
options for bacterial infections, particularly impacting those with chronic conditions such as …

Background While the emergence of chronic and mucoid Pseudomonas aeruginosa (Pa)
infection are both associated with poorer outcomes among CF patients, their relationship is …

The failure of antibiotic therapy in respiratory tract infections in cystic fibrosis is partly due to
the high tolerance observed in Pseudomonas aeruginosa biofilms. This tolerance is …

Background Early diagnosis and treatment of lower respiratory tract infections is the
mainstay of management of lung disease in cystic fibrosis (CF). When sputum samples are …

Strains of Pseudomonas aeruginosa with deficiencies in DNA mismatch repair have been
studied in the context of chronic infection, where elevated mutational rates (“hypermutation”) …