Oxidative stress is a complex biological process characterized by the excessive production
of reactive oxygen species (ROS) that act as destroyers of the REDOX balance in the body …

Diabetes mellitus is one of the major public health problems worldwide. Considerable recent
evidence suggests that the cellular reduction-oxidation (redox) imbalance leads to oxidative …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as
important second messengers within the cells; however, an imbalance between generation …

Background Quercetin, a bioflavonoid abundant in grapefruit, onion, berries, etc., has vast
therapeutic potential, especially against Type 2 diabetes and its complications. Quercetin …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Diabetic macroangiopathy, atherosclerosis secondary to diabetes mellitus (DM), causes
cerebro-cardiovascular diseases, which are major causes of death in patients with DM and …

Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes,
and can accelerate diabetes-related microvascular and macrovascular complications by …

In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …

The continuing increase in the prevalence of diabetes mellitus in the general population is
predicted to result in a higher incidence of cardiovascular disease. Although the …