The precise interplay of hormonal influences that governs gonadotropin hormone production
by the pituitary includes endocrine, paracrine and autocrine actions of hypothalamic …

Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH
from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH …

Type 2 diabetes, often associated with obesity, results from a deficiency of insulin production
and action manifested in increased blood levels of glucose and lipids that further promote …

Increased glucocorticoid secretion is a common response to stress and has been implicated
as a mediator of reproductive suppression upon the pituitary gland. We utilized …

The synthesis and secretion of the gonadotropic hormones involves coordination of signal
transduction, gene expression, protein translation, post-translational folding and …

Kisspeptin signaling through its receptor, Kiss1R, is crucial for many reproductive functions
including puberty, sex steroid feedback, and overall fertility. Although the importance of …

The pituitary gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone
(FSH) play a pivotal role in reproduction. The synthesis and secretion of gonadotropins are …

The objective of the present study was to compare the effect of a single versus multiple
doses of a 10-amino acid fragment of human (hKp) or murine (mKp) kisspeptin on LH …

In mammals, elevated levels of progesterone (P4) throughout gestation maintain a negative
feedback over the hypothalamic-hypophyseal-gonadal (HHG) axis, avoiding preovulatory …

Synthesis of luteinizing hormone (LH) is tightly controlled by a complex network of hormonal
signaling pathways that can be modulated by metabolic cues, such as insulin. One group of …