Mapping human brain function is a long-standing goal of neuroscience that promises to
inform the development of new treatments for brain disorders. Early maps of human brain …

Transcranial magnetic stimulation (TMS) is an effective treatment for depression but is
limited in that the optimal therapeutic target remains unknown. Early TMS trials lacked a …

Objective: Depression is the leading cause of disability worldwide, and half of patients with
depression have treatment-resistant depression. Intermittent theta-burst stimulation (iTBS) is …

Damage to specific brain circuits can cause specific neuropsychiatric symptoms.
Therapeutic stimulation to these same circuits may modulate these symptoms. To determine …

Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …

The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex
(DLPFC) is an established treatment for refractory depression, however, therapeutic …

Major depressive disorder is a remarkably common and often severe psychiatric disorder
associated with high levels of morbidity and mortality. Patients with major depression are …

Human prefrontal cortex (hPFC) is a complex brain region involved in cognitive and
emotional processes and several psychiatric disorders. Here, we present an overview of the …

The amygdala processes valenced stimuli, influences emotion, and exhibits aberrant activity
across anxiety disorders, depression, and PTSD. Interventions modulating amygdala activity …