Ischemic heart disease is associated with high morbidity and mortality rates. Reperfusion
therapy is the best treatment option for this condition. However, reperfusion can aggravate …

In myocardial ischemia/reperfusion injury (MIRI), moderate mitophagy is a protective or
adaptive mechanism because of clearing defective mitochondria accumulates during MIRI …

Mitophagy plays a significant role in modulating the activation of pyrin domain-containing
protein 3 (NLRP3) inflammasome, which is a major contributor to the inflammatory response …

Aims Cardiomyocyte apoptosis is an important factor leading to the occurrence and
development of heart failure (HF), which is associated with high mortality of patients with …

Background Myocardial ischemia/reperfusion injury (MI/RI) is involved in a variety of
pathological states for which there is no effective treatment exists. Shuangshen Ningxin …

Acute pancreatitis (AP) continues to pose a major challenge as targeted therapeutic
interventions are absent. Mitochondrial dysfunction and inflammasome-dependent …

Cardiovascular disease (CVD) is a serious public health risk, and prevention and treatment
efforts are urgently needed. Effective preventive and therapeutic programs for …

Organelle damage is a significant contributor to myocardial ischemia/reperfusion (I/R) injury.
This damage often leads to disruption of endoplasmic reticulum protein regulatory programs …

急性心肌梗死(acute myocardial infarction, AMI) 目前是我国主要引起致残率和致死率的重大
疾病, 其诊断主要依靠心电图变化和心肌肌钙蛋白, 心肌肌钙蛋白的增高可以提示AMI …

The detrimental effects arising from acute myocardial infarction (AMI) due to
ischemia/reperfusion injury (IRI) impair cardiac function through adverse cardiac …