The mammalian carboxylesterases: from molecules to functions
T Satoh, M Hosokawa - Annual review of pharmacology and …, 1998 - annualreviews.org
▪ Abstract Multiple carboxylesterases (EC 3.1. 1.1) play an important role in the hydrolytic
biotransformation of a vast number of structurally diverse drugs. These enzymes are major …
biotransformation of a vast number of structurally diverse drugs. These enzymes are major …
Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan
G Xu, W Zhang, MK Ma, HL McLeod - Clinical Cancer Research, 2002 - AACR
The prodrug irinotecan is an active agent for the treatment of advanced colorectal cancer
and a number of other solid tumors. Irinotecan is converted in vivo to SN-38 (7-ethyl-10 …
and a number of other solid tumors. Irinotecan is converted in vivo to SN-38 (7-ethyl-10 …
Pharmacokinetic characterization of BMS‐936561, an anti‐CD70 antibody‐drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in …
H Wang, VS Rangan, MC Sung… - … & Drug Disposition, 2016 - Wiley Online Library
CD70 is a tumor necrosis factor (TNF)‐like type II integral membrane protein that is
transiently expressed on activated T‐and B‐lymphocytes. Aberrant expression of CD70 was …
transiently expressed on activated T‐and B‐lymphocytes. Aberrant expression of CD70 was …
[图书][B] In vitro and in vivo characterization of the contribution of hepatic and serum A-esterases and carboxylesterases to detoxication of organophosphate oxons in the …
TA Couch - 2001 - search.proquest.com
The present study was designed to investigate the in vitro and in vivo contribution of hepatic
and serum carboxylesterases (CaE) and A-esterases (AEST) to their respective …
and serum carboxylesterases (CaE) and A-esterases (AEST) to their respective …
[图书][B] Role of structure-activity relationships in substrate specificity of carboxylesterases
EMA Kodsi - 2002 - search.proquest.com
Site directed mutagenesis is used to identify critical residues that dictate cholesteryl ester
hydrolase (CEH) activity, substrate specificity and sensitivity to protein kinase activation in …
hydrolase (CEH) activity, substrate specificity and sensitivity to protein kinase activation in …