[HTML][HTML] Bridging the gap of axonal regeneration in the central nervous system: a state of the art review on central axonal regeneration
G Costa, FF Ribeiro, AM Sebastião, EM Muir… - Frontiers in …, 2022 - frontiersin.org
Neuronal regeneration in the central nervous system (CNS) is an important field of research
with relevance to all types of neuronal injuries, including neurodegenerative diseases. The …
with relevance to all types of neuronal injuries, including neurodegenerative diseases. The …
Cytoskeleton saga: Its regulation in normal physiology and modulation in neurodegenerative disorders
Cells are fundamental units of life. To ensure the maintenance of homeostasis, integrity of
structural and functional counterparts is needed to be essentially balanced. The …
structural and functional counterparts is needed to be essentially balanced. The …
Schwann cell‐specific RhoA knockout accelerates peripheral nerve regeneration via promoting Schwann cell dedifferentiation
J Liu, X Ma, X Hu, J Wen, H Zhang, J Xu, Y He, X Wang… - Glia, 2023 - Wiley Online Library
Our previous studies indicated that RhoA knockdown or inhibition could alleviate the
proliferation, migration, and differentiation of Schwann cells. However, the role of RhoA in …
proliferation, migration, and differentiation of Schwann cells. However, the role of RhoA in …
Echinococcus multilocularis drives the polarization of macrophages by regulating the RhoA-MAPK signaling pathway and thus affects liver fibrosis
S Chong, G Chen, Z Dang, F Niu, L Zhang, H Ma… - …, 2022 - Taylor & Francis
Echinococcus multilocularis is a small parasite that causes alveolar echinococcosis. It
primarily induces liver disorder, such as liver fibrosis and even liver cancer, which severely …
primarily induces liver disorder, such as liver fibrosis and even liver cancer, which severely …
[HTML][HTML] Chondroitin Sulfate Proteoglycans Revisited: its Mechanism of Generation and Action for Spinal Cord Injury
R Yang, Y Zhang, J Kang, C Zhang, B Ning - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Reactive astrocytes (RAs) produce chondroitin sulfate proteoglycans (CSPGs) in large
quantities after spinal cord injury (SCI) and inhibit axon regeneration through the Rho …
quantities after spinal cord injury (SCI) and inhibit axon regeneration through the Rho …
[HTML][HTML] Rho kinase inhibitor Y27632 improves Recovery after spinal cord Injury by shifting astrocyte phenotype and morphology via the ROCK/NF-κB/C3 pathway
Y Zhang, X Wang, C Jiang, Z Chen, S Ni, H Fan… - Neurochemical …, 2022 - Springer
Spinal cord injury (SCI) usually results in loss or reduction in motor and sensory functions.
Despite extensive research, no available therapy can restore the lost functions after SCI …
Despite extensive research, no available therapy can restore the lost functions after SCI …
Structural insights into the interactions of belumosudil with rho-associated coiled-coil containing protein kinases 1 and 2 based on molecular docking, molecular …
M Shi, J Liu, S Fu, H Pei, B Peng, Y Wen… - Journal of …, 2023 - World Scientific
Rho-associated coiled-coil containing protein kinases (ROCKs) are members of the cyclic
adenosine monophosphate-dependent protein kinase/protein kinase G/protein kinase C …
adenosine monophosphate-dependent protein kinase/protein kinase G/protein kinase C …
Investigating LIM (Lin-11, Isl-1, and Mec-3) Kinases and Their Correlation with Pathological Events and Microtubule Dynamics in an Experimental Model of Spinal …
The spinal cord injury (SCI) and the neurodegenerative processes accompanying it follow
an intricate pathway with very limited options for treatment strategies until now. Microtubules …
an intricate pathway with very limited options for treatment strategies until now. Microtubules …
Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives
Y Gao, Y Wang, Y Wu, S Liu - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, and autonomic
function. There is currently no effective treatment for SCI. SCI occurs within three temporal …
function. There is currently no effective treatment for SCI. SCI occurs within three temporal …
Building a Pathway to Recovery: Targeting ECM Remodeling in CNS Injuries
AM Butt, V Rupareliya, A Hariharan, H Kumar - Brain Research, 2023 - Elsevier
Extracellular matrix (ECM) is a complex and dynamic network of proteoglycans, proteins,
and other macromolecules that surrounds cells in tissues. The ECM provides structural …
and other macromolecules that surrounds cells in tissues. The ECM provides structural …