[HTML][HTML] Bridging the gap of axonal regeneration in the central nervous system: a state of the art review on central axonal regeneration

G Costa, FF Ribeiro, AM Sebastião, EM Muir… - Frontiers in …, 2022 - frontiersin.org
Neuronal regeneration in the central nervous system (CNS) is an important field of research
with relevance to all types of neuronal injuries, including neurodegenerative diseases. The …

Cytoskeleton saga: Its regulation in normal physiology and modulation in neurodegenerative disorders

S Sen, S Lagas, A Roy, H Kumar - European Journal of Pharmacology, 2022 - Elsevier
Cells are fundamental units of life. To ensure the maintenance of homeostasis, integrity of
structural and functional counterparts is needed to be essentially balanced. The …

Schwann cell‐specific RhoA knockout accelerates peripheral nerve regeneration via promoting Schwann cell dedifferentiation

J Liu, X Ma, X Hu, J Wen, H Zhang, J Xu, Y He, X Wang… - Glia, 2023 - Wiley Online Library
Our previous studies indicated that RhoA knockdown or inhibition could alleviate the
proliferation, migration, and differentiation of Schwann cells. However, the role of RhoA in …

Echinococcus multilocularis drives the polarization of macrophages by regulating the RhoA-MAPK signaling pathway and thus affects liver fibrosis

S Chong, G Chen, Z Dang, F Niu, L Zhang, H Ma… - …, 2022 - Taylor & Francis
Echinococcus multilocularis is a small parasite that causes alveolar echinococcosis. It
primarily induces liver disorder, such as liver fibrosis and even liver cancer, which severely …

[HTML][HTML] Chondroitin Sulfate Proteoglycans Revisited: its Mechanism of Generation and Action for Spinal Cord Injury

R Yang, Y Zhang, J Kang, C Zhang, B Ning - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Reactive astrocytes (RAs) produce chondroitin sulfate proteoglycans (CSPGs) in large
quantities after spinal cord injury (SCI) and inhibit axon regeneration through the Rho …

[HTML][HTML] Rho kinase inhibitor Y27632 improves Recovery after spinal cord Injury by shifting astrocyte phenotype and morphology via the ROCK/NF-κB/C3 pathway

Y Zhang, X Wang, C Jiang, Z Chen, S Ni, H Fan… - Neurochemical …, 2022 - Springer
Spinal cord injury (SCI) usually results in loss or reduction in motor and sensory functions.
Despite extensive research, no available therapy can restore the lost functions after SCI …

Structural insights into the interactions of belumosudil with rho-associated coiled-coil containing protein kinases 1 and 2 based on molecular docking, molecular …

M Shi, J Liu, S Fu, H Pei, B Peng, Y Wen… - Journal of …, 2023 - World Scientific
Rho-associated coiled-coil containing protein kinases (ROCKs) are members of the cyclic
adenosine monophosphate-dependent protein kinase/protein kinase G/protein kinase C …

Investigating LIM (Lin-11, Isl-1, and Mec-3) Kinases and Their Correlation with Pathological Events and Microtubule Dynamics in an Experimental Model of Spinal …

A Roy, Z Pathak, H Kumar - ACS Pharmacology & Translational …, 2024 - ACS Publications
The spinal cord injury (SCI) and the neurodegenerative processes accompanying it follow
an intricate pathway with very limited options for treatment strategies until now. Microtubules …

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Y Gao, Y Wang, Y Wu, S Liu - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, and autonomic
function. There is currently no effective treatment for SCI. SCI occurs within three temporal …

Building a Pathway to Recovery: Targeting ECM Remodeling in CNS Injuries

AM Butt, V Rupareliya, A Hariharan, H Kumar - Brain Research, 2023 - Elsevier
Extracellular matrix (ECM) is a complex and dynamic network of proteoglycans, proteins,
and other macromolecules that surrounds cells in tissues. The ECM provides structural …