Post-inflammatory scarring is the end-result of excessive extracellular matrix (ECM)
accumulation and tissue architectural destruction. It represents a failure to effectively …

Crohn's disease (CD) is a chronic remitting and relapsing disease. Fibrostenosing
complications such as intestinal strictures, stenosis and ultimately obstruction are some of its …

Objective: To assess the role of fibroblasts, transforming growth factor (TGF)-β, and cell
signal pathways in promoting fibrosis in Crohn's disease (CD). Summary Background Data …

Background Crohn's disease (CD) is a chronic bowel inflammation that ultimately leads to
fibrosis, for which medical therapy is currently unavailable. Fibrotic strictures in CD are …

Abstract Interleukin 1 (IL-1) is an important mediator of inflammation and tissue damage in
inflammatory bowel disease (IBD). The balance between IL-1 and IL-1Ra as a natural …

Intestinal fibrosis is a serious complication in inflammatory bowel disease (IBD). Despite the
remarkable success of recent anti-inflammatory therapies for IBD, incidence of intestinal …

The matrix metalloproteinases (MMPs), MMP-2 and MMP-9, share structural and substrate
similarities and are up-regulated during human as well as animal models of inflammatory …

Background and aims: Colonic epithelial cells and adjacent subepithelial myofibroblasts are
important counterparts in the pathogenesis of intestinal inflammation and fibrosis. We …

Transforming growth factor β (TGF‐β) is known to play a key role in intestinal fibrosis;
however, the underlying mechanisms are not well understood. TGF‐β signal transduction is …

This article shall give an overview on drug delivery systems for new therapeutic strategies in
the treatment of inflammatory bowel disease. The various features of the different …