Abstract Background Returning stenosis in Crohn's disease (CD) patients is poorly
understood. After resection, newly developed strictures are seen within 10 years in 50% to …

Background Tissue inhibitors of metalloproteinases (TIMPs) play a key role in tissue
degradation and remodeling. Since chronic inflammation is associated with tissue …

Background Transforming growth factor‐β (TGF‐β)/Smad3 signalling plays a central role in
tissue fibrogenesis, acting as a potent stimulus of extracellular matrix (ECM) protein …

To understand whether postprandial extracellular Ca2+ (Cao2+) changes were related to
intestinal epithelial homeostasis, we performed array analysis on extracellular calcium …

BACKGROUND & AIMS: Inflammatory bowel diseases (IBDs) are characterized by
remodeling of the intestinal mucosa, which is associated with excessive cytokine release …

Intestinal fibrosis–a chronic and progressive process mediated by several factors–occurs in
several fibrostenosing enteropathies, but most frequently in patients with Crohn's disease …

Fibroblasts represent the key cell type in fibrostenosing Crohn's disease (FCD)
pathogenesis. S100A4 is an EF-hand calcium-binding protein family member, implicated in …

Matrix metalloproteinases (MMP s) are critical factors in maintaining the integrity of mucosa
and mediating normal biological processes. An imbalance between tissue levels of these …

AIM: To examine the expression of matrix metallo-proteinase-1 (MMP-1) and tumor necrosis
factor-α (TNF-α) in the colon mucosa of patients with ulcerative colitis (UC). METHODS …

Abstract Inflammatory Bowel Disease (IBD) is nonspecific inflammation in the intestinal track,
including Ulcerative Colitis (UC) and Crohn's disease (CD). The incidence of IBD has …