Non-motor features of Parkinson disease

AHV Schapira, KR Chaudhuri, P Jenner - Nature Reviews …, 2017 - nature.com
Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …

Depression in patients with Parkinson's disease: current understanding of its neurobiology and implications for treatment

S Prange, H Klinger, C Laurencin, T Danaila… - Drugs & Aging, 2022 - Springer
Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

Effectiveness of physical activity on patients with depression and Parkinson's disease: a systematic review

PL Wu, M Lee, TT Huang - PloS one, 2017 - journals.plos.org
Aim In this paper we aimed to systematically review the literature on physical activity's effect
on depressive symptoms in Parkinson disease. Background Depression is a common …

[HTML][HTML] Baicalein alleviates depression-like behavior in rotenone-induced Parkinson's disease model in mice through activating the BDNF/TrkB/CREB pathway

X Zhao, D Kong, Q Zhou, G Wei, J Song, Y Liang… - Biomedicine & …, 2021 - Elsevier
Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder in the world. In addition to motor symptoms, a variety of non-motor symptoms …

Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?

X Du, TY Pang - Frontiers in psychiatry, 2015 - frontiersin.org
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Psychosis, apathy, depression and anxiety in Parkinson's disease

DA Gallagher, A Schrag - Neurobiology of disease, 2012 - Elsevier
Psychiatric symptoms are important non-motor features in PD, which occur at high frequency
and have significant impact on health related quality of life. This review concentrates on the …

The T herapeutic P otential of E xercise to I mprove M ood, C ognition, and S l eep in P arkinson's D isease

GO Reynolds, MW Otto, TD Ellis… - Movement …, 2016 - Wiley Online Library
In addition to the classic motor symptoms, Parkinson's disease (PD) is associated with a
variety of nonmotor symptoms that significantly reduce quality of life, even in the early stages …

Pathological influences on clinical heterogeneity in Lewy body diseases

DG Coughlin, HI Hurtig, DJ Irwin - Movement Disorders, 2020 - Wiley Online Library
ABSTRACT PD, PD with dementia, and dementia with Lewy bodies are clinical syndromes
characterized by the neuropathological accumulation of alpha‐synuclein in the CNS that …

The pathobiological basis of depression in Parkinson disease: challenges and outlooks

KA Jellinger - Journal of neural transmission, 2022 - Springer
Depression, with an estimated prevalence of about 40% is a most common neuropsychiatric
disorder in Parkinson disease (PD), with a negative impact on quality of life, cognitive …

Risk of Parkinson disease after depression: a nationwide population-based study

CC Shen, SJ Tsai, CL Perng, BIT Kuo, AC Yang - Neurology, 2013 - AAN Enterprises
Objective: To evaluate the risk of Parkinson disease (PD) among patients with depression by
using the Taiwan National Health Insurance Research Database (NHIRD). Methods: We …