Interferon-gamma (IFN-γ) has been identified as a crucial factor in determining the
responsiveness to immunotherapy. Produced primarily by natural killer (NK) and T cells, IFN …

Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous tumor comprising
pancreatic cancer cells, fibroblasts, immune cells, vascular epithelial cells, and other cells in …

Euphorbiasteroid (EPBS) has gained attention for its activity against human lung cancer and
sarcoma; however, its impact on hepatocellular carcinoma has not yet been elucidated …

Background The dilemma of pancreatic cancer treatment has become a global challenge.
For this reason, effective, feasible, and new medical methods are currently much-needed …

Simple Summary Signal Transducer and Activator of Transcription 3 (STAT3) is involved in
many normal cellular processes that are tightly regulated. However, aberrant activation of …

An increasing number of studies have documented atypical protein kinase C isoform ι
(PKCι) as an oncoprotein playing multifaceted roles in pancreatic carcinogenesis, including …

Marine natural product (MNP) pretrichodermamide B (Pre B, 9) was identified as a novel
STAT3 inhibitor in our previous work, while its metabolic instability hindered its further …

Despite advances in cancer treatment, pancreatic cancer (PC) remains a disease with high
mortality rates and poor survival outcomes. The B7 homolog 3 (B7-H3) checkpoint molecule …

As a key pathological feature of pancreatic ductal adenocarcinoma (PDAC), the dense
extracellular matrix (ECM) limits the penetration of chemotherapy drugs and is involved in …

Mitogen-activated protein kinase inhibitors (MAPKi) were the first line drugs for advanced
melanoma patients with BRAF mutation. Targeted therapies have significant therapeutic …