Multimorbidity (two or more coexisting conditions in an individual) is a growing global
challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a …

With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Major depressive disorder (MDD) is characterized by psychological and physiological
manifestations contributing to the disease severity and outcome. In recent years, several …

Aging represents the single greatest risk factor for chronic diseases, including osteoporosis,
a skeletal fragility syndrome that increases fracture risk. Optimizing bone strength throughout …

Cellular senescence refers to a process induced by various types of stress that causes
irreversible cell cycle arrest and distinct cellular alterations, including profound changes in …

Altered mitochondria activity in osteoblasts and osteoclasts has been implicated in the loss
of bone mass associated with aging and estrogen deficiency—the 2 most common causes of …

The sirtuin family of NAD+-dependent protein deacetylases promotes longevity and
counteracts age-related diseases. One of the major targets of Sirtuins are the FoxO family of …

Senescent cells have detrimental effects across tissues with aging but may have beneficial
effects on tissue repair, specifically on skin wound healing. However, the potential role of …

Estrogen deficiency is a seminal mechanism in the pathogenesis of osteoporosis. Mounting
evidence, however, establishes that cellular senescence, a fundamental mechanism that …

Energy metabolism plays an important role in cell and tissue ability to effectively function,
maintain homeostasis, and perform repair. Yet, the role of energy metabolism in skeletal …