As warned by Sir Alexander Fleming in his Nobel Prize address:“the use of antimicrobials
can, and will, lead to resistance”. Antimicrobial resistance (AMR) has recently increased due …

Patients in intensive care units (ICU) are at high risk to experience potential drug-drug
interactions (pDDIs) because of the complexity of their drug regimens. Such pDDIs may be …

Background Augmented renal clearance (ARC) is associated with lower blood plasma
concentrations of renally excreted drugs; however, its time course is unknown. The current …

Objectives The use of extended intermittent infusion (EII) or continuous infusion (CI) of
meropenem is recommended in intensive care unit (ICU) patients, but few data comparing …

重症监护患者(ICU) 肾功能亢进(augmented renal clearance, ARC) 发生率高,
且由于此类患者常合并感染, ARC 的发生会使其对抗菌药物的清除率显著增加 …

Therapeutic drug monitoring (TDM) of plasma samples is used in many circumstances to
adjust pharmaceutics to desired concentrations. It is predominantly employed for drugs with …

Background Augmented renal clearance is increasingly recognized in critically ill patients.
This condition may lead to suboptimal dosing of renally excreted medications. Aim Our …

Purpose To demonstrate the feasibility of continuous infusion of meropenem–vaborbactam
to optimize the treatment of carbapenem-resistant Enterobacterales. Methods Report of a …

Background We analyzed the attainment of early pharmacological targets of continuous
infusion meropenem and piperacillin/tazobactam and the use and effect of a real-time …

Abstract Purpose of Review In this narrative review encompassing relevant scientific
publications regarding critically ill patients in the last 5 years, we discuss key questions …