There are two severe obstacles in cancer immunotherapy. The first is that the low response
rate challenges the immune response owing to the immunosuppressive tumor …

The cyclooxygenase-2 (COX-2) is a potent enzyme that converts arachidonic acid to
prostaglandins (PG), including PGE2, a key mediator of inflammation and angiogenesis …

Mucosal head and neck squamous cell carcinoma (HNSCC) are the seventh most common
cancer, with approximately 50% of patients living beyond 5 years. Immune checkpoint …

Eukaryotic initiation factor 5A2 (eIF5A2) is overexpressed in many types of cancer, and
spermidine-mediated eIF5A hypusination (eIF5Ahpu) appears to be essential to most of …

Background Having emerged as the most abundant posttranscriptional internal mRNA
modification in eukaryotes, N6‐methyladenosine (m6A) has attracted tremendous scientific …

Head and neck squamous cell carcinoma (HNSC) is one of the leading causes of cancer
death globally, yet there are few useful biomarkers for early identification and prognostic …

Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive solid tumor, with
a 5-year mortality rate of~ 50%. The development of immunotherapies has improved the …

Background Tumor-resident microbiota has been documented for various cancer types. Oral
squamous cell carcinoma (OSCC) is also enriched with microbiota, while the significance of …

Nasopharyngeal carcinoma (NPC) is a malignancy with high metastatic and invasive nature.
Distant metastasis contributes substantially to treatment failure and mortality in NPC …

Complex interactions take place during cancer formation and progression. In this regard,
there has been increasing focus on the non-malignant cells that make up the tumour …