Oral submucous fibrosis (OSF) involves a high risk of malignant transformation and has
been implicated in oral cancer. Limited studies have been conducted on the role of OSF in …

Background Glucose metabolism in cancer associated fibroblasts (CAFs) within the tumor
microenvironment is a material and energy source for tumorigenesis and tumor …

Purpose: There is increasing effort to discover and integrate predictive and/or prognostic
biomarkers into treatment algorithms. While tissue-based methods can reveal tumor …

Considering the great energy and biomass demand for cell survival, cancer cells exhibit
unique metabolic signatures compared to normal cells. Head and neck squamous cell …

Defective DNA damage response (DDR) is frequently associated with tumorigenesis.
Abrogation of DDR leads to genomic instability, which is one of the most common …

The 5-year overall survival rate remains approximately 50% for head and neck (H&N)
cancer patients, even though new cancer drugs have been approved for clinical use since …

Head and neck squamous cell carcinomas (HNSCCs) are often aggressive, making
advanced disease very difficult to treat using contemporary modalities, such as surgery …

Background In the malignant progression of oral leukoplakia (OLK) to oral squamous cell
carcinoma (OSCC), the density of microvessels and expression of angiogenesis‐related …

Background CD161 has been linked to the appearance and development of various
cancers. Methods The mutation map and the variation of CNVs and SNVs of CD161 were …

Head and neck cancer, one of the most commonly prevalent malignancies globally is a
complex category of tumours that comprises cancers of the oral cavity, pharynx, and larynx …