[HTML][HTML] Hallmarks of cancer: the next generation
D Hanahan, RA Weinberg - cell, 2011 - cell.com
The hallmarks of cancer comprise six biological capabilities acquired during the multistep
development of human tumors. The hallmarks constitute an organizing principle for …
development of human tumors. The hallmarks constitute an organizing principle for …
Glioma CpG island methylator phenotype (G-CIMP): biological and clinical implications
Gliomas are a heterogeneous group of brain tumors with distinct biological and clinical
properties. Despite advances in surgical techniques and clinical regimens, treatment of high …
properties. Despite advances in surgical techniques and clinical regimens, treatment of high …
[HTML][HTML] Navigating the DNA methylation landscape of cancer
A Nishiyama, M Nakanishi - Trends in Genetics, 2021 - cell.com
DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …
control of gene expression and genome stability. Disruption of DNA methylation control …
Melanocytic nevi and melanoma: unraveling a complex relationship
WE Damsky, M Bosenberg - Oncogene, 2017 - nature.com
Approximately 33% of melanomas are derived directly from benign, melanocytic nevi.
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …
Distinct DNA methylomes of newborns and centenarians
Human aging cannot be fully understood in terms of the constrained genetic setting.
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …
DNA methylation profiling in the clinic: applications and challenges
H Heyn, M Esteller - Nature Reviews Genetics, 2012 - nature.com
Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …
development of genome-wide techniques for their identification. The ever-growing number …
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
S Shukla, E Kavak, M Gregory, M Imashimizu… - Nature, 2011 - nature.com
Alternative splicing of pre-messenger RNA is a key feature of transcriptome expansion in
eukaryotic cells, yet its regulation is poorly understood. Spliceosome assembly occurs co …
eukaryotic cells, yet its regulation is poorly understood. Spliceosome assembly occurs co …
Epigenetics and colorectal cancer
VV Lao, WM Grady - Nature reviews Gastroenterology & hepatology, 2011 - nature.com
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …
Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
DNA methylation is the most studied epigenetic mark and CpG methylation is central to
many biological processes and human diseases. Since cancer has highlighted the …
many biological processes and human diseases. Since cancer has highlighted the …
[HTML][HTML] Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
We report the identification of 67 previously undescribed histone modifications, increasing
the current number of known histone marks by about 70%. We further investigated one of the …
the current number of known histone marks by about 70%. We further investigated one of the …