Gene–environment interactions have been traditionally understood to promote the
acquisition of mutations that drive multistage carcinogenesis, and, in the case of inherited …

Post-translational modifications diversify protein functions and dynamically coordinate their
signalling networks, influencing most aspects of cell physiology. Nevertheless, their genetic …

Disruption of the histone modification patterns is one of the most common features of human
tumors. However, few genetic alterations in the histone modifier genes have been described …

Diabetes mellitus and breast cancer are two important health problems. Type 2 diabetes
(T2DM) and obesity are closely linked with both being associated with breast cancer …

The completion of genome, epigenome, and transcriptome mapping in multiple cell types
has created a demand for precision biomolecular tools that allow researchers to functionally …

Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease and one
of the most common inherited tumor predisposition syndromes, affecting 1 in 3000 …

Chromatin factors that regulate neurogenesis in the central nervous system remain to be
explored. Here, we demonstrate that the chromatin remodeler chromodomain-helicase-DNA …

Carbon-based quantum dots (CQDs) have been shown to have promising application value
in tumor diagnosis. Their use, however, is severely hindered by the complicated nature of …

Abstract miR-155 acts as an oncogenic miR in B-cell lymphoproliferative disorders,
including Waldenstrom macroglobulinemia (WM) and chronic lymphocytic leukemia, and is …

Background Breast cancer is the most frequent cancer among women worldwide.
Biomarkers for early detection and prognosis of these patients are needed. We …