DNA methylation dynamics in cellular commitment and differentiation
M Suelves, E Carrió, Y Núñez-Álvarez… - Briefings in functional …, 2016 - academic.oup.com
DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …
[HTML][HTML] Precision medicine and public health: new challenges for effective and sustainable health
D Traversi, A Pulliero, A Izzotti, E Franchitti… - Journal of Personalized …, 2021 - mdpi.com
The development of high-throughput omics technologies represents an unmissable
opportunity for evidence-based prevention of adverse effects on human health. However …
opportunity for evidence-based prevention of adverse effects on human health. However …
O-GlcNAc signaling in cancer metabolism and epigenetics
The covalent attachment of β-DN-acetylglucosamine monosaccharides (O-GlcNAc) to
serine/threonine residues of nuclear and cytoplasmic proteins is a major regulatory …
serine/threonine residues of nuclear and cytoplasmic proteins is a major regulatory …
Role of multidrug resistance-associated proteins in cancer therapeutics: past, present, and future perspectives
Cancer, a major public health problem, is one of the world's top leading causes of death.
Common treatments for cancer include cytotoxic chemotherapy, surgery, targeted drugs …
Common treatments for cancer include cytotoxic chemotherapy, surgery, targeted drugs …
[HTML][HTML] Epigenomic evolution in diffuse large B-cell lymphomas
The contribution of epigenomic alterations to tumour progression and relapse is not well
characterized. Here we characterize an association between disease progression and DNA …
characterized. Here we characterize an association between disease progression and DNA …
[HTML][HTML] Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer
Human papillomaviruses (HPVs) are double stranded circular DNA viruses that infect
cutaneous and mucosal epithelial cells. Almost 99% of cervical cancer has a HPV infection …
cutaneous and mucosal epithelial cells. Almost 99% of cervical cancer has a HPV infection …
[HTML][HTML] Human papilloma virus, DNA methylation and microRNA expression in cervical cancer
H Jiménez-Wences, O Peralta-Zaragoza… - Oncology …, 2014 - spandidos-publications.com
Cancer is a complex disease caused by genetic and epigenetic abnormalities that affect
gene expression. The progression from precursor lesions to invasive cervical cancer is …
gene expression. The progression from precursor lesions to invasive cervical cancer is …
[HTML][HTML] Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA
H Wu, S Guo, X Liu, Y Li, Z Su, Q He, X Liu, Z Zhang… - BMC medicine, 2022 - Springer
Background Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate
primarily due to the late onset of symptoms and rapid progression. Reliable and accurate …
primarily due to the late onset of symptoms and rapid progression. Reliable and accurate …
DNA methylation contributes to the regulation of sclerostin expression in human osteocytes
J Delgado‐Calle, C Sañudo, A Bolado… - Journal of Bone and …, 2012 - academic.oup.com
Sclerostin, encoded by the SOST gene, is a potent inhibitor of bone formation, produced by
osteocytes, not by osteoblasts, but little is known about the molecular mechanisms …
osteocytes, not by osteoblasts, but little is known about the molecular mechanisms …
[HTML][HTML] A DNA methylation map of human cancer at single base-pair resolution
Although single base-pair resolution DNA methylation landscapes for embryonic and
different somatic cell types provided important insights into epigenetic dynamics and cell …
different somatic cell types provided important insights into epigenetic dynamics and cell …