DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …

The development of high-throughput omics technologies represents an unmissable
opportunity for evidence-based prevention of adverse effects on human health. However …

The covalent attachment of β-DN-acetylglucosamine monosaccharides (O-GlcNAc) to
serine/threonine residues of nuclear and cytoplasmic proteins is a major regulatory …

Cancer, a major public health problem, is one of the world's top leading causes of death.
Common treatments for cancer include cytotoxic chemotherapy, surgery, targeted drugs …

The contribution of epigenomic alterations to tumour progression and relapse is not well
characterized. Here we characterize an association between disease progression and DNA …

Human papillomaviruses (HPVs) are double stranded circular DNA viruses that infect
cutaneous and mucosal epithelial cells. Almost 99% of cervical cancer has a HPV infection …

Cancer is a complex disease caused by genetic and epigenetic abnormalities that affect
gene expression. The progression from precursor lesions to invasive cervical cancer is …

Background Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate
primarily due to the late onset of symptoms and rapid progression. Reliable and accurate …

Sclerostin, encoded by the SOST gene, is a potent inhibitor of bone formation, produced by
osteocytes, not by osteoblasts, but little is known about the molecular mechanisms …

Although single base-pair resolution DNA methylation landscapes for embryonic and
different somatic cell types provided important insights into epigenetic dynamics and cell …