Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
Design and functionalization strategies for multifunctional nanocarriers (eg, nanoparticles,
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …
Curcumin: the Indian solid gold
BB Aggarwal, C Sundaram, N Malani… - The molecular targets and …, 2007 - Springer
Turmeric, derived from the plant Curcuma longa, is a gold-colored spice commonly used in
the Indian subcontinent, not only for health care but also for the preservation of food and as …
the Indian subcontinent, not only for health care but also for the preservation of food and as …
Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo
Alzheimer's disease (AD) involves amyloid β (Aβ) accumulation, oxidative damage, and
inflammation, and risk is reduced with increased antioxidant and anti-inflammatory …
inflammation, and risk is reduced with increased antioxidant and anti-inflammatory …
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
GP Lim, T Chu, F Yang, W Beech… - Journal of …, 2001 - Soc Neuroscience
Inflammation in Alzheimer's disease (AD) patients is characterized by increased cytokines
and activated microglia. Epidemiological studies suggest reduced AD risk associates with …
and activated microglia. Epidemiological studies suggest reduced AD risk associates with …
Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance
RA Sharma, SA Euden, SL Platton, DN Cooke… - Clinical cancer …, 2004 - AACR
Curcumin, a polyphenolic antioxidant derived from a dietary spice, exhibits anticancer
activity in rodents and in humans. Its efficacy appears to be related to induction of …
activity in rodents and in humans. Its efficacy appears to be related to induction of …
Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro
Inhibition of the accumulation of amyloid β‐peptide (Aβ) and the formation of β‐amyloid
fibrils (fAβ) from Aβ, as well as the destabilization of preformed fAβ in the central nervous …
fibrils (fAβ) from Aβ, as well as the destabilization of preformed fAβ in the central nervous …
Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer
RA Sharma, HR McLelland, KA Hill, CR Ireson… - Clinical Cancer …, 2001 - AACR
Curcuma spp. extracts, particularly the dietary polyphenol curcumin, prevent colon cancer in
rodents. In view of the sparse information on the pharmacodynamics and pharmacokinetics …
rodents. In view of the sparse information on the pharmacodynamics and pharmacokinetics …
Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers
R Jamwal - Journal of integrative medicine, 2018 - Elsevier
Curcumin is a widely studied natural compound which has shown tremendous in vitro
therapeutic potential. Despite that, the clinical efficacy of the native curcumin is weak due to …
therapeutic potential. Despite that, the clinical efficacy of the native curcumin is weak due to …
Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease
AN Begum, MR Jones, GP Lim, T Morihara… - … of Pharmacology and …, 2008 - ASPET
Curcumin can reduce inflammation and neurodegeneration, but its chemical instability and
metabolism raise concerns, including whether the more stable metabolite …
metabolism raise concerns, including whether the more stable metabolite …
Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine
CR Ireson, DJL Jones, S Orr, MWH Coughtrie… - … Biomarkers & Prevention, 2002 - AACR
Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of
rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent …
rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent …