As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of
cellular processes, including cell polarity, cell migration, and cell cycle progression. The …

Integrins are a family of heterodimeric receptors that bind to components of the extracellular
matrix and influence cellular processes as varied as proliferation and migration. These …

Cortactin fulfills many functions in various cell types. These functions have been considered
to derive from its ability to activate the Actin-related protein 2/3 (Arp2/3) complex, and are …

Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based
on 3D migration models has revealed a diversity of invasive migratory schemes reflecting …

Loss of apical–basal polarity and activation of epithelial–mesenchymal transition (EMT) both
contribute to carcinoma progression and metastasis. Here, we report that apical–basal …

Membrane-type matrix metalloproteases (MT-MMP) are pivotal regulators of cell invasion,
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …

Apico-basal polarity is typical of cells present in differentiated epithelium while front-rear
polarity develops in motile cells. In cancer development, the transition from epithelial to …

Invasion of cancer cells into collagen-rich extracellular matrix requires membrane-tethered
membrane type 1–matrix metalloproteinase (MT1-MMP) as the key protease for collagen …

Carbonic anhydrase IX (CAIX) is a hypoxia inducible factor 1-induced, cell surface pH
regulating enzyme with an established role in tumor progression and clinical outcome …

ABSTRACT Three-dimensional (3D) cell motility underlies essential processes, such as
embryonic development, tissue repair and immune surveillance, and is involved in cancer …