The pathophysiology of thrombocytopenia in chronic liver disease
O Mitchell, DM Feldman, M Diakow… - … medicine: evidence and …, 2016 - Taylor & Francis
Thrombocytopenia is the most common hematological abnormality encountered in patients
with chronic liver disease (CLD). In addition to being an indicator of advanced disease and …
with chronic liver disease (CLD). In addition to being an indicator of advanced disease and …
Soluble transferrin receptor for the evaluation of erythropoiesis and iron status
Y Beguin - Clinica chimica acta, 2003 - Elsevier
Iron transport in the plasma is carried out by transferrin, which donates iron to cells through
its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble …
its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble …
Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans
PJ Stohlawetz, L Dzirlo, N Hergovich… - Blood, The Journal …, 2000 - ashpublications.org
A recent study in dogs suggested that erythropoietin (EPO) not only promotes the synthesis
of increased numbers of reticulated platelets but that these newly produced platelets are …
of increased numbers of reticulated platelets but that these newly produced platelets are …
Prediction of response and other improvements on the limitations of recombinant human erythropoietin therapy in anemic cancer patients
Y Beguin - Haematologica, 2002 - haematologica.org
BACKGROUND AND OBJECTIVES: The majority of cancer patients suffer from chronic
anemia. While recombinant human erythropoietin (rHuEPO) offers many of the advantages …
anemia. While recombinant human erythropoietin (rHuEPO) offers many of the advantages …
Platelet parameters in women with iron deficiency anemia.
G Kadikoylu, I Yavasoglu, Z Bolaman… - Journal of the national …, 2006 - ncbi.nlm.nih.gov
BACKGROUND: In iron deficiency anemia (IDA), several changes in platelets have been
reported. Therefore, a relationship between iron metabolism and thrombopoiesis should be …
reported. Therefore, a relationship between iron metabolism and thrombopoiesis should be …
Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin
R Evstatiev, A Bukaty, K Jimenez… - American journal of …, 2014 - Wiley Online Library
Iron deficiency is a common cause of reactive thrombocytosis, however, the exact pathways
have not been revealed. Here we aimed to study the mechanisms behind iron deficiency …
have not been revealed. Here we aimed to study the mechanisms behind iron deficiency …
Erythropoietin, iron depletion, and relative thrombocytosis: a possible explanation for hemoglobin-survival paradox in hemodialysis
BACKGROUND: High doses of human recombinant erythropoietin (rHuEPO) to achieve
hemoglobin levels greater than 13 g/dL in patients with chronic kidney disease appear to be …
hemoglobin levels greater than 13 g/dL in patients with chronic kidney disease appear to be …
Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805
F Baffert, CH Régnier, A De Pover… - Molecular cancer …, 2010 - AACR
The recent discovery of an acquired activating point mutation in JAK2, substituting valine at
amino acid position 617 for phenylalanine, has greatly improved our understanding of the …
amino acid position 617 for phenylalanine, has greatly improved our understanding of the …
New agents that stimulate erythropoiesis
HF Bunn - Blood, 2007 - ashpublications.org
Recombinant human erythropoietin (rhEpo) has proven to be remarkably safe and effective
for treatment of anemias, primarily those secondary to renal disease and malignancy …
for treatment of anemias, primarily those secondary to renal disease and malignancy …
Platelet counts in adults with iron deficiency anemia
In adults with iron deficiency anemia (IDA), abnormal platelet counts were seen in several
studies. However we retrospectively examined the clinical records of a larger number of …
studies. However we retrospectively examined the clinical records of a larger number of …