This review highlights the influence of oxygen (O2) availability on cerebral blood flow (CBF).
Evidence for reductions in O2 content (CaO2) rather than arterial O2 tension (PaO2) as the …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

A complex interrelation between lung and brain in patients with acute lung injury (ALI) has
been established by experimental and clinical studies during the last decades. Although …

Quantitative measurements of brain perfusion are influenced by perfusion-modifiers.
Standardization of measurement conditions and correction for important modifiers is …

The regulation and defence of intracellular pH is essential for homeostasis. Indeed,
alterations in cerebrovascular acid–base balance directly affect cerebral blood flow (CBF) …

Ascent to high-altitude elicits compensatory physiological adaptations in order to improve
oxygenation throughout the body. The brain is particularly vulnerable to the hypoxemia of …

New Findings What is the topic of this review? Cerebrovascular reactivity to CO2, which is a
principal factor in determining ventilatory responses to CO2 through the role reactivity plays …

High‐altitude (HA) hypoxia may alter the structural–functional integrity of the neurovascular
unit (NVU). Herein, we compared male lowlanders (n= 9) at sea level (SL) and after 14 days …

The cerebral vasculature manages oxygen delivery by adjusting arterial blood in‐flow in the
face of reductions in oxygen availability. Hypoxic cerebral vasodilatation, and the associated …

Key points We investigated the influence of arterial () with and without acutely elevated
arterial pH and bicarbonate ([HCO3–]) on cerebral blood flow (CBF) regulation in the …