Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

WB Dunn, DI Broadhurst, HJ Atherton… - Chemical society …, 2011 - pubs.rsc.org
The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …

[HTML][HTML] Radioprotection and radiomitigation: from the bench to clinical practice

E Obrador, R Salvador, JI Villaescusa, JM Soriano… - Biomedicines, 2020 - mdpi.com
The development of protective agents against harmful radiations has been a subject of
investigation for decades. However, effective (ideal) radioprotectors and radiomitigators …

Metabolomics-based methods for early disease diagnostics

GAN Gowda, S Zhang, H Gu, V Asiago… - Expert review of …, 2008 - Taylor & Francis
The emerging field of metabolomics, in which a large number of small-molecule metabolites
from body fluids or tissues are detected quantitatively in a single step, promises immense …

[HTML][HTML] Statistical methods for the analysis of high-throughput metabolomics data

J Bartel, J Krumsiek, FJ Theis - Computational and structural biotechnology …, 2013 - Elsevier
Metabolomics is a relatively new high-throughput technology that aims at measuring all
endogenous metabolites within a biological sample in an unbiased fashion. The resulting …

NMR-based metabolomics in human disease diagnosis: applications, limitations, and recommendations

AHM Emwas, RM Salek, JL Griffin, J Merzaban - Metabolomics, 2013 - Springer
Metabolomics is a dynamic and emerging research field, similar to proteomics,
transcriptomics and genomics in affording global understanding of biological systems. It is …

Pharmacometabonomics: data processing and statistical analysis

J Fu, Y Zhang, J Liu, X Lian, J Tang… - Briefings in …, 2021 - academic.oup.com
Individual variations in drug efficacy, side effects and adverse drug reactions are still
challenging that cannot be ignored in drug research and development. The aim of …

Metabolomics of four biofluids from dairy cows: potential biomarkers for milk production and quality

HZ Sun, DM Wang, B Wang, JK Wang… - Journal of proteome …, 2015 - ACS Publications
The fundamental understanding of the mechanisms regulating milk protein synthesis is
limited. This study aimed to elucidate the metabolic mechanisms of milk production affected …

Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes

WB Dunn - Physical biology, 2008 - iopscience.iop.org
The functional levels of biological cells or organisms can be separated into the genome,
transcriptome, proteome and metabolome. Of these the metabolome offers specific …

Application of metabolomics to cardiovascular biomarker and pathway discovery

GD Lewis, A Asnani, RE Gerszten - Journal of the American College of …, 2008 - jacc.org
Emerging technologies based on mass spectrometry and nuclear magnetic resonance
enable the monitoring of hundreds of metabolites from tissues or body fluids, that …

[HTML][HTML] Omic techniques in systems biology approaches to traditional Chinese medicine research: present and future

A Buriani, ML Garcia-Bermejo, E Bosisio, Q Xu… - Journal of …, 2012 - Elsevier
Omic techniques have become key tools in the development of systems biology. As the
holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new …