Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy
WB Dunn, DI Broadhurst, HJ Atherton… - Chemical society …, 2011 - pubs.rsc.org
The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …
[HTML][HTML] Radioprotection and radiomitigation: from the bench to clinical practice
The development of protective agents against harmful radiations has been a subject of
investigation for decades. However, effective (ideal) radioprotectors and radiomitigators …
investigation for decades. However, effective (ideal) radioprotectors and radiomitigators …
Metabolomics-based methods for early disease diagnostics
The emerging field of metabolomics, in which a large number of small-molecule metabolites
from body fluids or tissues are detected quantitatively in a single step, promises immense …
from body fluids or tissues are detected quantitatively in a single step, promises immense …
[HTML][HTML] Statistical methods for the analysis of high-throughput metabolomics data
J Bartel, J Krumsiek, FJ Theis - Computational and structural biotechnology …, 2013 - Elsevier
Metabolomics is a relatively new high-throughput technology that aims at measuring all
endogenous metabolites within a biological sample in an unbiased fashion. The resulting …
endogenous metabolites within a biological sample in an unbiased fashion. The resulting …
NMR-based metabolomics in human disease diagnosis: applications, limitations, and recommendations
Metabolomics is a dynamic and emerging research field, similar to proteomics,
transcriptomics and genomics in affording global understanding of biological systems. It is …
transcriptomics and genomics in affording global understanding of biological systems. It is …
Pharmacometabonomics: data processing and statistical analysis
J Fu, Y Zhang, J Liu, X Lian, J Tang… - Briefings in …, 2021 - academic.oup.com
Individual variations in drug efficacy, side effects and adverse drug reactions are still
challenging that cannot be ignored in drug research and development. The aim of …
challenging that cannot be ignored in drug research and development. The aim of …
Metabolomics of four biofluids from dairy cows: potential biomarkers for milk production and quality
HZ Sun, DM Wang, B Wang, JK Wang… - Journal of proteome …, 2015 - ACS Publications
The fundamental understanding of the mechanisms regulating milk protein synthesis is
limited. This study aimed to elucidate the metabolic mechanisms of milk production affected …
limited. This study aimed to elucidate the metabolic mechanisms of milk production affected …
Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes
WB Dunn - Physical biology, 2008 - iopscience.iop.org
The functional levels of biological cells or organisms can be separated into the genome,
transcriptome, proteome and metabolome. Of these the metabolome offers specific …
transcriptome, proteome and metabolome. Of these the metabolome offers specific …
Application of metabolomics to cardiovascular biomarker and pathway discovery
Emerging technologies based on mass spectrometry and nuclear magnetic resonance
enable the monitoring of hundreds of metabolites from tissues or body fluids, that …
enable the monitoring of hundreds of metabolites from tissues or body fluids, that …
[HTML][HTML] Omic techniques in systems biology approaches to traditional Chinese medicine research: present and future
A Buriani, ML Garcia-Bermejo, E Bosisio, Q Xu… - Journal of …, 2012 - Elsevier
Omic techniques have become key tools in the development of systems biology. As the
holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new …
holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new …