Insights into the pharmacogenetics of tacrolimus pharmacokinetics and pharmacodynamics
M Brunet, M Pastor-Anglada - Pharmaceutics, 2022 - mdpi.com
The influence of pharmacogenetics in tacrolimus pharmacokinetics and pharmacodynamics
needs further investigation, considering its potential in assisting clinicians to predict the …
needs further investigation, considering its potential in assisting clinicians to predict the …
Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1
AL Degraeve, V Haufroid, A Loriot, L Gatto, V Andries… - Microbiome, 2023 - Springer
Background Following solid organ transplantation, tacrolimus (TAC) is an essential drug in
the immunosuppressive strategy. Its use constitutes a challenge due to its narrow …
the immunosuppressive strategy. Its use constitutes a challenge due to its narrow …
Pharmacomicrobiomics: Immunosuppressive Drugs and Microbiome Interactions in Transplantation
The human microbiome is associated with human health and disease. Exogenous
compounds, including pharmaceutical products, are also known to be affected by the …
compounds, including pharmaceutical products, are also known to be affected by the …
Tacrolimus pharmacokinetics is associated with gut microbiota diversity in kidney transplant patients: results from a pilot cross‐sectional study
AL Degraeve, LB Bindels, V Haufroid… - Clinical …, 2024 - Wiley Online Library
Clinical use of tacrolimus (TAC), an essential immunosuppressant following transplantation,
is complexified by its high pharmacokinetic (PK) variability. The gut microbiota gains …
is complexified by its high pharmacokinetic (PK) variability. The gut microbiota gains …
Genetic polymorphisms affecting tacrolimus metabolism and the relationship to post-transplant outcomes in kidney transplant recipients
F Cheng, Q Li, J Wang, M Hu, F Zeng… - Pharmacogenomics …, 2021 - Taylor & Francis
Background Tacrolimus is a key drug in kidney transplantation with a narrow therapeutic
index. However, whether tacrolimus exposure variability affects clinical outcomes and …
index. However, whether tacrolimus exposure variability affects clinical outcomes and …
Tacrolimus concentration is effectively predicted using combined clinical and genetic factors in the perioperative period of kidney transplantation and associated with …
F Cheng, Q Li, Z Cui, Z Wang, F Zeng… - Journal of Immunology …, 2022 - Wiley Online Library
Background. Tacrolimus has unpredictable pharmacokinetic (PK) characteristics, which are
partially attributed to CYP3A5 polymorphism. The potential effects of clinical factors in the …
partially attributed to CYP3A5 polymorphism. The potential effects of clinical factors in the …
Effects and safety evaluation of Wuzhi Capsules combined with tacrolimus for the treatment of kidney transplantation recipients
F Cheng, Q Li, J Wang, F Zeng… - Journal of Clinical …, 2021 - Wiley Online Library
What is known and objective Tacrolimus (FK506), an effective and potent calcineurin
inhibitor, is the cornerstone of immunosuppression after kidney transplantation. Wuzhi …
inhibitor, is the cornerstone of immunosuppression after kidney transplantation. Wuzhi …
The impact of CYP3A4 and CYP3A5 genetic variations on tacrolimus treatment of living‐donor Egyptian kidney transplanted patients
H Wanas, MH Kamel, EA William… - Journal of Clinical …, 2023 - Wiley Online Library
Background Tacrolimus (TAC) is the mainstay of immunosuppressive regimen for kidney
transplantations. Its clinical use is complex due to high inter‐individual variations which can …
transplantations. Its clinical use is complex due to high inter‐individual variations which can …
Importance of Pharmacogenetics and Drug–Drug Interactions in a Kidney Transplanted Patient
J Concha, E Sangüesa, AM Saez-Benito, I Aznar… - Life, 2023 - mdpi.com
Tacrolimus (TAC) is a narrow-therapeutic-range immunosuppressant drug used after organ
transplantation. A therapeutic failure is possible if drug levels are not within the therapeutic …
transplantation. A therapeutic failure is possible if drug levels are not within the therapeutic …
Extreme phenotype sampling and next generation sequencing to identify genetic variants associated with tacrolimus in African American kidney transplant recipients
African American (AA) kidney transplant recipients (KTRs) have poor outcomes, which may
in-part be due to tacrolimus (TAC) sub-optimal immunosuppression. We previously …
in-part be due to tacrolimus (TAC) sub-optimal immunosuppression. We previously …