Molecular targets of tyrosine kinase inhibitors in thyroid cancer

P Fallahi, SM Ferrari, MR Galdiero, G Varricchi… - Seminars in cancer …, 2022 - Elsevier
Thyroid cancer (TC) is the eighth most frequently diagnosed cancer worldwide with a rising
incidence in the past 20 years. Surgery is the primary strategy of therapy for patients with …

Novel inhibitor-based therapies for thyroid cancer—An update

M Ratajczak, D Gaweł, M Godlewska - International journal of molecular …, 2021 - mdpi.com
Thyroid cancers (TCs) are the most common tumors of the endocrine system and a constant
rise in the number of TC cases has been observed for the past few decades. TCs are one of …

Lenvatinib compared with sorafenib as a first-line treatment for radioactive iodine-refractory, progressive, differentiated thyroid carcinoma: real-world outcomes in a …

M Kim, M Jin, MJ Jeon, EY Kim, DY Shin, DJ Lim… - Thyroid, 2023 - liebertpub.com
Background: Sorafenib and lenvatinib have been widely adopted to treat radioactive iodine
(RAI)-refractory differentiated thyroid carcinoma (DTC). However, limited data exist …

Thyroglobulin and thyroglobulin antibody: an updated clinical and laboratory expert consensus

L Giovanella, F D'Aurizio… - European journal of …, 2023 - academic.oup.com
Objective Thyroglobulin measurement is the cornerstone of modern management of
differentiated thyroid cancer, with clinical decisions on treatment and follow-up based on the …

Real-world efficacy and safety of multi-tyrosine kinase inhibitors in radioiodine refractory thyroid cancer

VF Koehler, E Berg, P Adam, GL Weber, A Pfestroff… - Thyroid, 2021 - liebertpub.com
Background: The management of patients with locally advanced or metastatic differentiated
thyroid cancer (DTC) that is refractory to radioiodine (RAI) remains a therapeutic challenge …

Nursing management and adverse events in thyroid cancer treatments with tyrosine kinase inhibitors. A narrative review

A De Leo, E Di Simone, A Spano, G Puliani, F Petrone - Cancers, 2021 - mdpi.com
Simple Summary Tyrosine kinase inhibitors are an effective and promising therapy in the
treatment of advanced differentiated medullary thyroid cancers. The prevention and …

Long-term results of a phase II trial of apatinib for progressive radioiodine refractory differentiated thyroid cancer

YS Lin, X Zhang, C Wang, YQ Liu… - The Journal of …, 2021 - academic.oup.com
Context Radioiodine refractory differentiated thyroid cancer (RAIR-DTC) has been a global
challenge due to its poor prognosis and limited treatment options. Objective We report here …

Management of hypertension during lenvatinib for advanced thyroid cancer: a suggested diagnostic and therapeutic algorithm

C Colombo, D Ceruti, S De Leo, G Bilo… - European Thyroid …, 2023 - etj.bioscientifica.com
Background Hypertension (HTN) is the most frequent adverse event during treatment with
lenvatinib (LEN), but data on its best management are limited. Aim The objective of this …

Nephrotoxicity in advanced thyroid cancer treated with tyrosine kinase inhibitors: an update

A Nervo, F Retta, A Ragni, A Piovesan, A Mella… - Critical Reviews in …, 2021 - Elsevier
Over the past decade, the prognosis of advanced thyroid cancer (TC) patients has
dramatically improved thanks to the introduction of tyrosine kinase inhibitors (TKIs). Despite …

Long-term management of lenvatinib-treated thyroid cancer patients: a real-life experience at a single institution

T Porcelli, C Luongo, F Sessa, M Klain, S Masone… - Endocrine, 2021 - Springer
Purpose The efficacy of lenvatinib for advanced and progressive radioactive iodine
refractory differentiated thyroid cancer is well established. Herein, we retrospectively …