Precision medicine in human heart modeling: perspectives, challenges, and opportunities
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
Constrained mixture models of soft tissue growth and remodeling–twenty years after
JD Humphrey - Journal of Elasticity, 2021 - Springer
Soft biological tissues compromise diverse cell types and extracellular matrix constituents,
each of which can possess individual natural configurations, material properties, and rates …
each of which can possess individual natural configurations, material properties, and rates …
A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions
NCA van Engeland, AMAO Pollet, JMJ den Toonder… - Lab on a Chip, 2018 - pubs.rsc.org
Cell signalling and mechanics influence vascular pathophysiology and there is an
increasing demand for in vitro model systems that enable examination of signalling between …
increasing demand for in vitro model systems that enable examination of signalling between …
Mechanical homeostasis in tissue equivalents: a review
There is substantial evidence that growth and remodeling of load bearing soft biological
tissues is to a large extent controlled by mechanical factors. Mechanical homeostasis, which …
tissues is to a large extent controlled by mechanical factors. Mechanical homeostasis, which …
[HTML][HTML] Immuno-regenerative biomaterials for in situ cardiovascular tissue engineering–Do patient characteristics warrant precision engineering?
BJ De Kort, SE Koch, TB Wissing, MM Krebber… - Advanced Drug Delivery …, 2021 - Elsevier
In situ tissue engineering using bioresorbable material implants-or scaffolds-that harness
the patient's immune response while guiding neotissue formation at the site of implantation …
the patient's immune response while guiding neotissue formation at the site of implantation …
Advances in wireless, batteryless, implantable electronics for real-time, continuous physiological monitoring
This review summarizes recent progress in developing wireless, batteryless, fully
implantable biomedical devices for real-time continuous physiological signal monitoring …
implantable biomedical devices for real-time continuous physiological signal monitoring …
Homogenized constrained mixture models for anisotropic volumetric growth and remodeling
Constrained mixture models for soft tissue growth and remodeling have attracted increasing
attention over the last decade. They can capture the effects of the simultaneous presence of …
attention over the last decade. They can capture the effects of the simultaneous presence of …
Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress
NCA van Engeland, F Suarez Rodriguez… - Scientific reports, 2019 - nature.com
The intermediate filament (IF) cytoskeleton has been proposed to regulate morphogenic
processes by integrating the cell fate signaling machinery with mechanical cues. Signaling …
processes by integrating the cell fate signaling machinery with mechanical cues. Signaling …
A computational framework for modeling cell–matrix interactions in soft biological tissues
Living soft tissues appear to promote the development and maintenance of a preferred
mechanical state within a defined tolerance around a so-called set point. This phenomenon …
mechanical state within a defined tolerance around a so-called set point. This phenomenon …
Inelastic material formulations based on a co-rotated intermediate configuration—application to bioengineered tissues
In the field of material modeling, there is a general trend to include more and more complex
phenomena in the modeling, making the models' theoretical derivation and numerical …
phenomena in the modeling, making the models' theoretical derivation and numerical …