Precision medicine in human heart modeling: perspectives, challenges, and opportunities

M Peirlinck, FS Costabal, J Yao, JM Guccione… - … and modeling in …, 2021 - Springer
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …

Constrained mixture models of soft tissue growth and remodeling–twenty years after

JD Humphrey - Journal of Elasticity, 2021 - Springer
Soft biological tissues compromise diverse cell types and extracellular matrix constituents,
each of which can possess individual natural configurations, material properties, and rates …

A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

NCA van Engeland, AMAO Pollet, JMJ den Toonder… - Lab on a Chip, 2018 - pubs.rsc.org
Cell signalling and mechanics influence vascular pathophysiology and there is an
increasing demand for in vitro model systems that enable examination of signalling between …

Mechanical homeostasis in tissue equivalents: a review

JF Eichinger, LJ Haeusel, D Paukner, RC Aydin… - … and modeling in …, 2021 - Springer
There is substantial evidence that growth and remodeling of load bearing soft biological
tissues is to a large extent controlled by mechanical factors. Mechanical homeostasis, which …

[HTML][HTML] Immuno-regenerative biomaterials for in situ cardiovascular tissue engineering–Do patient characteristics warrant precision engineering?

BJ De Kort, SE Koch, TB Wissing, MM Krebber… - Advanced Drug Delivery …, 2021 - Elsevier
In situ tissue engineering using bioresorbable material implants-or scaffolds-that harness
the patient's immune response while guiding neotissue formation at the site of implantation …

Advances in wireless, batteryless, implantable electronics for real-time, continuous physiological monitoring

H Kim, B Rigo, G Wong, YJ Lee, WH Yeo - Nano-Micro Letters, 2024 - Springer
This review summarizes recent progress in developing wireless, batteryless, fully
implantable biomedical devices for real-time continuous physiological signal monitoring …

Homogenized constrained mixture models for anisotropic volumetric growth and remodeling

FA Bräu, A Seitz, RC Aydin, CJ Cyron - Biomechanics and modeling in …, 2017 - Springer
Constrained mixture models for soft tissue growth and remodeling have attracted increasing
attention over the last decade. They can capture the effects of the simultaneous presence of …

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

NCA van Engeland, F Suarez Rodriguez… - Scientific reports, 2019 - nature.com
The intermediate filament (IF) cytoskeleton has been proposed to regulate morphogenic
processes by integrating the cell fate signaling machinery with mechanical cues. Signaling …

A computational framework for modeling cell–matrix interactions in soft biological tissues

JF Eichinger, MJ Grill, ID Kermani, RC Aydin… - … and modeling in …, 2021 - Springer
Living soft tissues appear to promote the development and maintenance of a preferred
mechanical state within a defined tolerance around a so-called set point. This phenomenon …

Inelastic material formulations based on a co-rotated intermediate configuration—application to bioengineered tissues

H Holthusen, C Rothkranz, L Lamm, T Brepols… - Journal of the …, 2023 - Elsevier
In the field of material modeling, there is a general trend to include more and more complex
phenomena in the modeling, making the models' theoretical derivation and numerical …