[HTML][HTML] Alternative Transcription Start Site Usage and Functional Implications in Pathogenic Fungi

TTV Dang, J Colin, G Janbon - Journal of Fungi, 2022 - mdpi.com
Pathogenic fungi require delicate gene regulation mechanisms to adapt to diverse living
environments and escape host immune systems. Recent advances in sequencing …

The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans

BJ Chadwick, T Pham, X Xie, LC Ristow, DJ Krysan… - Elife, 2022 - elifesciences.org
The environmental pathogen Cryptococcus neoformans claims over 180,000 lives each
year. Survival of this basidiomycete at host CO 2 concentrations has only recently been …

Proteome signatures reveal homeostatic and adaptive oxidative responses by a putative co-chaperone, Wos2, to influence fungal virulence determinants in …

B Ball, A Sukumaran, S Pladwig, S Kazi… - Microbiology …, 2024 - Am Soc Microbiol
The increasing prevalence of invasive fungal pathogens is dramatically changing the clinical
landscape of infectious diseases, posing an imminent threat to public health. Specifically …

Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction

CM Knowles, D Goich, ALM Bloom, MC Kalem… - Mbio, 2023 - Am Soc Microbiol
In response to the host environment, the human pathogen Cryptococcus neoformans must
rapidly reprogram its translatome from one which promotes growth to one which is …

The interactome of Cryptococcus neoformans Rmt5 reveals multiple regulatory points in fungal cell biology and pathogenesis

MC Kalem, H Subbiah, S Shen, R Chen, L Terry, Y Sun… - bioRxiv, 2022 - biorxiv.org
Protein arginine methylation is a key post-translational modification in eukaryotes that
modulates core cellular processes, including translation, morphology, transcription, and …

[图书][B] Methionine synthases as targets for antifungal drug development

J Scott - 2023 - search.proquest.com
Fungal infections pose an urgent threat to human health and are responsible for
approximately 1.6 million deaths annually. Current therapeutic options for lifethreatening …