Introduction: The purpose of this systematic review is to provide supporting evidence for the
clinical practice guideline for the treatment of obstructive sleep apnea (OSA) in adults using …

In this second part of a 2-part series on the global burden of cardiovascular disease, we
review the proven, effective approaches to the prevention and treatment of cardiovascular …

Disclaimer 2017: The EACTS Guidelines represent the views of the EACTS and were
produced after careful consideration of the scientific and medical knowledge and the …

Introduction Despite clear guidelines recommendations, most patients with heart failure and
reduced ejection–fraction (HFrEF) do not attain guideline-recommended target doses. We …

Objective To determine the comparative effectiveness of exercise versus drug interventions
on mortality outcomes. Design Metaepidemiological study. Eligibility criteria Meta-analyses …

The incidence and prevalence of hypertension is increasing worldwide, with approximately
1.13 billion of people currently affected by the disease, often in association with other …

Background—Treatments that reduce mortality and morbidity in patients with heart failure
with reduced ejection fraction, including angiotensin-converting enzyme inhibitors (ACEI) …

Objectives: Describe the different types and stages of heart failure. Identify the etiologies and
epidemiology of heart failure. Explain the clinical signs and symptoms of heart failure …

Adrenergic receptors (AR) are G-protein-coupled receptors (GPCRs) that have a crucial role
in cardiac physiology in health and disease. Alpha1-ARs signal through G α q, and signaling …

Objective: To comparatively analyze the efficacy, acceptability, and tolerability of various
augmentation agents in adult patients with treatment-resistant depression. Data Sources: An …