Vascular inflammation is associated with and in large part driven by changes in the
leukocyte compartment of the vessel wall. Here, we focus on monocyte influx during …

Steroid hormones are an important class of regulatory molecules that are synthesized in
steroidogenic cells of the adrenal, ovary, testis, placenta, brain, and skin, and influence a …

Tumor cell lines are often used as models for the study of nanoparticle− cell interactions.
Here we demonstrate that carboxy (PS-COOH) and amino functionalized (PS-NH2) …

Perfluorooctanoic acid (PFOA,'C8') and perfluoroctane sulphonate (PFOS) are
environmentally stable compounds with industrial and consumer uses and long half-lives in …

Atherosclerosis is a chronic, inflammatory disorder characterized by the deposition of excess
lipids in the arterial intima. The formation of macrophage-derived foam cells in a plaque is a …

Low levels of HDL cholesterol are a significant predictor of atherosclerotic cardiovascular
events. HDL is believed to protect against atherosclerosis by promoting reverse cholesterol …

Several lines of research indicate that osteoarthritis (OA) is not only a joint disorder
associated with mechanical stress and aging but also a 'metabolic syndrome'in which …

Although systemically applied nanoparticles are quickly taken up by phagocytic cells, mainly
macrophages, the interactions between engineered nanoparticles and macrophages are …

Cholesterol homeostasis is maintained through the coordinated regulation of the trafficking,
biosynthesis, absorption, and efflux of cholesterol. From the discovery that atherosclerotic …

Altered lipid metabolism has been implicated as a critical player in osteoarthritis (OA). Our
study aimed to investigate the expression of genes regulating cholesterol efflux in human …