Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …

Small cell lung cancer (SCLC) is notorious for its early and frequent metastases, which
contribute to it as a recalcitrant malignancy. To understand the molecular mechanisms …

The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

Colorectal tumor is a heterogeneous disease, with varying clinical presentation and
prognosis in patients. To establish a platform encompassing this diversity, we generated 55 …

Background Classification using class-imbalanced data is biased in favor of the majority
class. The bias is even larger for high-dimensional data, where the number of variables …

Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard
of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year …

Since the completion of the first human genome sequence and the advent of next generation
sequencing technologies, remarkable progress has been made in understanding the …

Metastases represent the end products of a multistep cell-biological process termed the
invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically …

Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators
of vascular morphogenesis and function during development, cardiovascular homeostasis …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …