Somatic cells that change from one mature phenotype to another exhibit the property of
plasticity. It is increasingly clear that epithelial and endothelial cells enjoy some of this …

Metastasis to distant organs is an ominous feature of most malignant tumours but the natural
history of this process varies in different cancers. The cellular origin, intrinsic properties of …

The extracellular matrix (ECM) is a key regulator of cell and tissue function. Traditionally, the
ECM has been thought of primarily as a physical scaffold that binds cells and tissues …

Brain metastasis frequently occurs in individuals with cancer and is often fatal. We used
multiphoton laser scanning microscopy to image the single steps of metastasis formation in …

Non-small cell lung cancer (NSCLC) accounts for> 80% of lung cancer cases and currently
has an overall five-year survival rate of only 15%. Patients presenting with advanced stage …

Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The
importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less …

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as
prototypes for growth factor and receptor tyrosine kinase function for more than 25 years …

Metastasis is a multistep process during which cancer cells disseminate from the site of
primary tumors and establish secondary tumors in distant organs. In a search for key …

Background Selection of relevant genes for sample classification is a common task in most
gene expression studies, where researchers try to identify the smallest possible set of genes …

There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer.
S1P regulates processes such as inflammation, which can drive tumorigenesis; …