[HTML][HTML] Levels of caspase-3 and histidine-rich glycoprotein in the embryo secretome as biomarkers of good-quality day-2 embryos and high-quality blastocysts

H Kaihola, FG Yaldir, T Bohlin, R Samir, J Hreinsson… - PLoS …, 2019 - journals.plos.org
Morphological assessment at defined developmental stages is the most important method to
select viable embryos for transfer and cryopreservation. Timing of different developmental …

Differences in secretome in culture media when comparing blastocysts and arrested embryos using multiplex proximity assay

KE Lindgren, F Gülen Yaldir, J Hreinsson… - Upsala journal of …, 2018 - Taylor & Francis
Objectives: The aim of this study was to assess different patterns of the human embryo
secretome analysed as protein levels in culture media. Furthermore, analyses to correlate …

Oocyte and embryo evaluation by AI and multi-spectral auto-fluorescence imaging: livestock embryology needs to catch-up to clinical practice

HJ McLennan, A Saini, KR Dunning, JG Thompson - Theriogenology, 2020 - Elsevier
A highly accurate 'non-invasive quantitative embryo assessment for pregnancy'(NQEAP)
technique that determines embryo quality has been an elusive goal. If developed, NQEAP …

Viewing early life without labels: optical approaches for imaging the early embryo

DJX Chow, TCY Tan, A Upadhya, M Lim… - Biology of …, 2024 - academic.oup.com
Embryo quality is an important determinant of successful implantation and a resultant live
birth. Current clinical approaches for evaluating embryo quality rely on subjective …

[HTML][HTML] A validated model for individualized prediction of pregnancy outcome in woman after fresh cycle of Day 5 single blastocyst transfer

L Chen, R Jiang, Y Jiang, Y Su, S Wang - Scientific Reports, 2023 - nature.com
The association between the embryo quality, clinical characteristics, miRNAs (secreted by
blastocysts in the culture medium) and pregnancy outcomes has been well-established …

Circulating MMP-7 and VEGF as potential predictive biomarkers for recurrent implantation failures

M Benkhalifa, W Zidi, H Bahri, S Mahjoub, K Boudhraa… - Zygote, 2021 - cambridge.org
Recurrent implantation failure (RIF) is considered to be one of the major limiting factors of
assisted reproductive technology (ART) programme success. The current study focused on …

Mitochondrial bioenergetic profiles of warmed bovine blastocysts are typically altered after cryopreservation by slow freezing and vitrification

J Kurzella, D Miskel, F Rings, E Tholen, D Tesfaye… - Theriogenology, 2024 - Elsevier
The widespread use of cryopreserved in vitro produced (IVP) bovine embryos is limited due
to their low post-warming viability compared to their ex vivo derived counterparts. Therefore …

Metabolic Regulation of preimplantation Embryo Development in vivo and in vitro: Molecular Mechanisms and insights

SH Lee, PF Rinaudo - Biochemical and Biophysical Research …, 2024 - Elsevier
Understanding of embryonic development has led to the clinical application of Assisted
Reproductive technologies (ART), with the resulting birth of millions of children. Recent …

[HTML][HTML] Effects of low-dose X-ray medical diagnostics on female gonads: Insights from large animal oocytes and human ovaries as complementary models

NA Martino, R Vicenti, M Macciocca, R Seracchioli… - Plos one, 2021 - journals.plos.org
Diagnostic imaging has significantly grown over the last thirty years as indispensable
support for diagnostic, prognostic, therapeutic and monitoring procedures of human …

Microfluidics and microanalytics to facilitate quantitative assessment of human embryo physiology

DK Gardner, P Reineck, BC Gibson… - In Vitro Fertilization: A …, 2019 - Springer
Morphological assessment of the human preimplantation embryo has been used for 40
years to try to quantitate developmental potential. Although certain traits of embryo …