Recruitment and expansion of tregs cells in the tumor environment—how to target them?

J Cinier, M Hubert, L Besson, A Di Roio, C Rodriguez… - Cancers, 2021 - mdpi.com
Simple Summary The immune response against cancer is generated by effector T cells,
among them cytotoxic CD8+ T cells that destroy cancer cells and helper CD4+ T cells that …

CCR4 in cutaneous T‐cell lymphoma: Therapeutic targeting of a pathogenic driver

JP Nicolay, JD Albrecht… - European Journal of …, 2021 - Wiley Online Library
New treatments are needed for patients with cutaneous T‐cell lymphoma (CTCL),
particularly for advanced mycosis fungoides (MF) and Sezary syndrome (SS). The …

Immunoregulatory signal networks and tumor immune evasion mechanisms: Insights into therapeutic targets and agents in clinical development

Q Wei, K Taskén - Biochemical Journal, 2022 - portlandpress.com
Through activation of immune cells, the immune system is responsible for identifying and
destroying infected or otherwise damaged cells including tumorigenic cells that can be …

Chemokine systems in oncology: From microenvironment modulation to nanocarrier innovations

M Guan, S Liu, YG Yang, Y Song, Y Zhang… - International Journal of …, 2024 - Elsevier
Over the past few decades, significant strides have been made in understanding the pivotal
roles that chemokine networks play in tumor biology. These networks, comprising …

548 Phase 2 study of FLX475 in combination with ipilimumab in advanced melanoma

R Goyal, N Nasrah, D Johnson, W Ho - 2021 - jitc.bmj.com
Background Regulatory T cells (Treg) can dampen antitumor immune responses in the
tumor microenvironment (TME) and have been shown to correlate with poor clinical …