Summary European Respiratory Society guidelines for the management of adult
bronchiectasis highlight the paucity of treatment options available for patients with this …

Cathepsin C (CatC) is a cysteine dipeptidyl aminopeptidase that activates most of tissue-
degrading elastase-related serine proteases. Thus, CatC appears as a potential therapeutic …

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl
aminopeptidase. The best characterized physiological function of CatC is the activation of …

Anti-neutrophil cytoplasmic autoantibodies (ANCA) targeting proteinase 3 (PR3) and
myeloperoxidase expressed by innate immune cells (neutrophils and monocytes) are salient …

Neutrophil serine proteases (NSPs), such as neutrophil elastase (NE), are activated by
dipeptidyl peptidase 1 (DPP1) during neutrophil maturation. High NSP levels can be …

Cathepsin C, an important lysosomal cysteine protease, mediates the maturation process of
neutrophil serine proteases, and participates in the inflammation and immune regulation …

Introduction Neutrophilic inflammation is a major driver of bronchiectasis pathophysiology,
and neutrophil elastase activity is the most promising biomarker evaluated in sputum to date …

The loss of smell (anosmia) related to SARS-CoV-2 infection is one of the most common
symptoms of COVID-19. Olfaction starts in the olfactory epithelium mainly composed of …

Epidemiological studies established an association between chronic inflammation and
higher risk of cancer. Inhibition of proteolytic enzymes represents a potential treatment …

Herein, we describe a [2+ 1] annulation reaction of di/trifluorodiazoethane with (alkylidene)
malononitriles. This protocol offers a streamlined synthesis of a wide range of stereospecific …