Microbial communities that colonize the human gastrointestinal (GI) tract defend against
pathogens through a mechanism known as colonization resistance (CR). Advances in …

The complement system is an evolutionarily conserved arm of innate immunity, which forms
one of the first lines of host response to pathogens, and assists in the clearance of debris. A …

Proteins and peptides found in human milk have bioactive potential to benefit the newborn
and support healthy development. Research has been carried out on the health benefits of …

Breastfeeding has a major impact on the health of infants. In a recent study published in
Cell, Xu et al. identify and disentangle a novel molecular role of the maternal complement …

Milk is a complex biochemical fluid that includes macronutrients and microbiota, which,
together, are known to facilitate infant growth, mediate the colonization of infant …

Complement, traditionally perceived as a liver-derived and plasma-operative guardian
against bloodborne pathogens, is increasingly recognized as a local and central player in …

Complement proteins form a proteolytic cascade to clear invading microbes. In a recent
issue of Cell, Wu et al. and Xu et al. demonstrate two distinct complement systems operating …

Therapeutic recombinant proteins are powerful tools used for the treatment of many
detrimental diseases such as diabetes, cancer, multiple sclerosis, rheumatoid arthritis …

Graphical abstract Abstract Milk is an ancient, fundamental mammalian adaptation that
provides nutrition and biochemical communication to offspring. Microbiomes have been …

Breast milk is known to contain antibodies and other immune mediators that provide immune
protection and shape the gut microbiota. It also contains complement proteins—however …