Since the discovery of chlorpromazine (CPZ) in 1952, first-generation antipsychotics (FGAs)
have revolutionized psychiatric care in terms of facilitating discharge from hospital and …

These updated guidelines from the British Association for Psychopharmacology replace the
original version published in 2011. They address the scope and targets of pharmacological …

Objective: To review evidence for the treatment of neuroleptic malignant syndrome (NMS)
and to discuss how to rechallenge patients with neuroleptics when continued …

ABSTRACT Introduction: The atypical antipsychotic (APs) drugs have become the most
widely used agents to treat a variety of psychoses because of their superiority with regard to …

Neuroleptic malignant syndrome is an unpredictable iatrogenic neurologic emergency
condition, mainly arising as an idiosyncratic reaction to antipsychotic agent use. It is …

Objective Neuroleptic malignant syndrome (NMS) is a potentially fatal, idiosyncratic reaction
to antipsychotics. Due to low incidence of NMS, research on risk factors of mortality …

Aripiprazole, brexpiprazole and cariprazine differ from all other second-generation
antipsychotics due to partial agonism at the dopamine D2 and D3 receptors. In contrast to …

Objectives To identify the clinical determinants of fever in clozapine users and their impact
on management of clozapine treatment. Methods Articles published in English or French …

Objective: To provide an overview of neuroleptic malignant syndrome (NMS) for the general
practitioner with the most up-to-date information on etiology, workup, and management …

The so-called “insight paradox” posits that among patients with schizophrenia higher levels
of insight are associated with increased levels of depression. Although different studies …