[HTML][HTML] Body fatness associations with cancer: evidence from recent epidemiological studies and future directions

SC Larsson, N Spyrou, CS Mantzoros - Metabolism, 2022 - Elsevier
This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …

[HTML][HTML] Risk factors for prostate cancer: An umbrella review of prospective observational studies and mendelian randomization analyses

H Cui, W Zhang, L Zhang, Y Qu, Z Xu, Z Tan… - Plos …, 2024 - journals.plos.org
Background The incidence of prostate cancer is increasing in older males globally. Age,
ethnicity, and family history are identified as the well-known risk factors for prostate cancer …

[HTML][HTML] Long-term outcomes of testosterone treatment in men: a T4DM postrandomization observational follow-up study

DJ Handelsman, M Grossmann, BB Yeap… - The Journal of …, 2024 - academic.oup.com
Abstract Context The T4DM study randomized 1007 men with impaired glucose tolerance or
newly diagnosed diabetes to testosterone undecanoate (TU, 1000 mg) or matching placebo …

[HTML][HTML] Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers

K Smith-Byrne, Å Hedman, M Dimitriou, T Desai… - Nature …, 2024 - nature.com
Circulating proteins can reveal key pathways to cancer and identify therapeutic targets for
cancer prevention. We investigate 2,074 circulating proteins and risk of nine common …

[HTML][HTML] Association between multiple sclerosis and prostate cancer risk: A systematic review and meta‑analysis

Z Hu, Y Fu, J Wang, Y Li, Q Jiang - Oncology letters, 2023 - spandidos-publications.com
Prostate cancer (PCa) risk in patients with multiple sclerosis (MS) remains to be elucidated.
The present study conducted a meta‑analysis to assess the relationship between MS and …

[HTML][HTML] Putative causal inference for the relationship between obesity and sex hormones in males: a bidirectional Mendelian randomization study

B Wan, N Ma, Z Zhou, C Lv - PeerJ, 2023 - peerj.com
Background Obesity is a chronic disease with a high prevalence rate and is an established
risk factor for human health. Body mass index (BMI) is a common and primary indicator used …

Genetic predisposition to metabolically unfavourable adiposity and prostate cancer risk: A Mendelian randomization analysis

A Perez‐Cornago, K Smith‐Byrne… - Cancer …, 2023 - Wiley Online Library
Background The associations of adiposity with aggressive prostate cancer risk are unclear.
Using two‐sample Mendelian randomization, we assessed the association of metabolically …

[HTML][HTML] Dysregulation of RNA-Exosome machinery is directly linked to major cancer hallmarks in prostate cancer: Oncogenic role of PABPN1

P Sáez-Martínez, F Porcel-Pastrana… - Cancer Letters, 2024 - Elsevier
Novel biomarkers and therapeutic strategies for prostate-cancer (PCa) are required to
overcome its lethal progression. The dysregulation/implication of the RNA-Exosome …

[HTML][HTML] Mendelian randomization evidence based on European ancestry for the causal effects of leukocyte telomere length on prostate cancer

X Wu, C Hu, T Wu, X Du, Z Peng, W Xue, Y Chen… - Human Genomics, 2024 - Springer
Background Several lines of evidence suggest that leukocyte telomere length (LTL) can
affect the development of prostate cancer (PC). Methods Here, we employed single …

Interactions of obesity, body shape, diabetes and sex steroids with respect to prostate cancer risk in the UK Biobank cohort

S Christakoudi, KK Tsilidis, E Evangelou… - Cancer …, 2024 - Wiley Online Library
Background Obesity and diabetes are associated inversely with low‐grade prostate cancer
risk and affect steroid hormone synthesis but whether they modify each other's impact on …