[HTML][HTML] Body fatness associations with cancer: evidence from recent epidemiological studies and future directions
This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …
various cancers, with focus on evidence from recent large cohort studies and pooled …
[HTML][HTML] Risk factors for prostate cancer: An umbrella review of prospective observational studies and mendelian randomization analyses
H Cui, W Zhang, L Zhang, Y Qu, Z Xu, Z Tan… - Plos …, 2024 - journals.plos.org
Background The incidence of prostate cancer is increasing in older males globally. Age,
ethnicity, and family history are identified as the well-known risk factors for prostate cancer …
ethnicity, and family history are identified as the well-known risk factors for prostate cancer …
[HTML][HTML] Long-term outcomes of testosterone treatment in men: a T4DM postrandomization observational follow-up study
DJ Handelsman, M Grossmann, BB Yeap… - The Journal of …, 2024 - academic.oup.com
Abstract Context The T4DM study randomized 1007 men with impaired glucose tolerance or
newly diagnosed diabetes to testosterone undecanoate (TU, 1000 mg) or matching placebo …
newly diagnosed diabetes to testosterone undecanoate (TU, 1000 mg) or matching placebo …
[HTML][HTML] Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers
Circulating proteins can reveal key pathways to cancer and identify therapeutic targets for
cancer prevention. We investigate 2,074 circulating proteins and risk of nine common …
cancer prevention. We investigate 2,074 circulating proteins and risk of nine common …
[HTML][HTML] Association between multiple sclerosis and prostate cancer risk: A systematic review and meta‑analysis
Z Hu, Y Fu, J Wang, Y Li, Q Jiang - Oncology letters, 2023 - spandidos-publications.com
Prostate cancer (PCa) risk in patients with multiple sclerosis (MS) remains to be elucidated.
The present study conducted a meta‑analysis to assess the relationship between MS and …
The present study conducted a meta‑analysis to assess the relationship between MS and …
[HTML][HTML] Putative causal inference for the relationship between obesity and sex hormones in males: a bidirectional Mendelian randomization study
B Wan, N Ma, Z Zhou, C Lv - PeerJ, 2023 - peerj.com
Background Obesity is a chronic disease with a high prevalence rate and is an established
risk factor for human health. Body mass index (BMI) is a common and primary indicator used …
risk factor for human health. Body mass index (BMI) is a common and primary indicator used …
Genetic predisposition to metabolically unfavourable adiposity and prostate cancer risk: A Mendelian randomization analysis
A Perez‐Cornago, K Smith‐Byrne… - Cancer …, 2023 - Wiley Online Library
Background The associations of adiposity with aggressive prostate cancer risk are unclear.
Using two‐sample Mendelian randomization, we assessed the association of metabolically …
Using two‐sample Mendelian randomization, we assessed the association of metabolically …
[HTML][HTML] Dysregulation of RNA-Exosome machinery is directly linked to major cancer hallmarks in prostate cancer: Oncogenic role of PABPN1
P Sáez-Martínez, F Porcel-Pastrana… - Cancer Letters, 2024 - Elsevier
Novel biomarkers and therapeutic strategies for prostate-cancer (PCa) are required to
overcome its lethal progression. The dysregulation/implication of the RNA-Exosome …
overcome its lethal progression. The dysregulation/implication of the RNA-Exosome …
[HTML][HTML] Mendelian randomization evidence based on European ancestry for the causal effects of leukocyte telomere length on prostate cancer
X Wu, C Hu, T Wu, X Du, Z Peng, W Xue, Y Chen… - Human Genomics, 2024 - Springer
Background Several lines of evidence suggest that leukocyte telomere length (LTL) can
affect the development of prostate cancer (PC). Methods Here, we employed single …
affect the development of prostate cancer (PC). Methods Here, we employed single …
Interactions of obesity, body shape, diabetes and sex steroids with respect to prostate cancer risk in the UK Biobank cohort
S Christakoudi, KK Tsilidis, E Evangelou… - Cancer …, 2024 - Wiley Online Library
Background Obesity and diabetes are associated inversely with low‐grade prostate cancer
risk and affect steroid hormone synthesis but whether they modify each other's impact on …
risk and affect steroid hormone synthesis but whether they modify each other's impact on …