Many bacterial pathogens can permanently colonize their host and establish either chronic
or recurrent infections that the immune system and antimicrobial therapies fail to eradicate …

Biofilms are a widespread multicellular form of bacterial life. The spatial structure and
emergent properties of these communities depend on a polymeric extracellular matrix …

Highlights•Growth versus maintenance/resilience is the overarching theme of cellular
regulation.•Why transition to multicellularity is integrated into the growth-versus-survival …

Highlights•Limitations in molecular resources for gene expression influence bacterial
physiology.•Bacteria optimise trade-offs between resource allocation and growth.•Resource …

Living organisms such as bacteria are often exposed to continuous changes in the nutrient
availability in nature. Therefore, bacteria must constantly monitor the environmental …

The asymmetric outer membrane (OM) of Gram-negative bacteria functions as a selective
permeability barrier to the environment. Perturbations to OM lipid asymmetry sensitize the …

Summary RelA-SpoT Homolog (RSH) enzymes control bacterial physiology through
synthesis and degradation of the nucleotide alarmone (p) ppGpp. We recently discovered …

Since antibiotic resistance is often associated with a fitness cost, bacteria employ multi-
layered regulatory mechanisms to ensure that expression of resistance factors is restricted to …

The intracellular small molecules 2′, 3′-cyclic nucleotide monophosphates (2′, 3′-
cNMPs) have recently been rediscovered within both prokaryotes and eukaryotes. Studies in …

Antibiotic tolerance—the ability of bacteria to survive for an extended time in the presence of
bactericidal antibiotics—is an understudied contributor to antibiotic treatment failure. Herein …