Formerly regarded purely as passive energy storage, adipose tissue is now recognized as a
vital endocrine organ. Adipocytes secrete diverse peptide hormones named adipokines …

The apelinergic system comprises two peptide ligands, apelin and ELABELA, and their
cognate G-protein-coupled receptor, the apelin receptor APJ. Apelin is a peptide that was …

Aims Activation of cardiac fibroblasts and their differentiation into myofibroblasts is a key
event in the progression of cardiac fibrosis that leads to end-stage heart failure. Apelin, an …

Apelin and its receptor APJ have pleiotropic effects in mice and humans and play a
protective role in cardiovascular diseases at least partially by inhibiting oxidative stress. Our …

Although Parkinson's disease (PD) is well known with its motor deficits, the patients often
suffer from cognitive dysfunction. Apelin, as the endogenous ligand of the APJ receptor, is …

BACKGROUND: Apelin is an endogenous ligand for the G-protein-coupled 7-
transmembrane receptor, APJ. The administration of apelin-13, a truncated 13-amino acid …

Background Targeting of the apelin–apelin receptor (Apj) system may serve as a useful
therapeutic intervention for the management of chronic kidney disease (CKD)‐induced …

Apelin is the endogenous ligand of the APJ receptor, a member of the G protein-coupled
receptor family. This system plays an important role in the regulation of blood pressure and …

Apelin and ELABELA (ELA), which are peptides belonging to the adipokines group, are
endogenous peptide ligands of their receptor, APJ, which together constitute the apelinergic …

The widespread distribution of apelin-13 and apelin receptors in the brain suggests an
important function of this neuropeptide in the brain that has not been explored extensively so …