Recent findings suggest that the cellular and extracellular materials surrounding the
cancerous cells from an atypical tumor microenvironment (TM) play a pivotal role in the …

Background Preventive therapy is a risk reduction option for women who have an increased
risk of breast cancer. The effectiveness of preventive therapy to reduce breast cancer …

Background Recent progress in understanding the genetic basis of breast cancer and
widely publicized reports of celebrities undergoing risk‐reducing mastectomy (RRM) have …

Several options for cancer prevention are available for women with a BRCA1 or BRCA2
mutation, including prophylactic surgery, chemoprevention and screening. The authors …

Purpose To determine whether adjuvant tamoxifen treatment for breast cancer (BC) is
associated with reduced contralateral breast cancer (CBC) risk for BRCA1 and/or BRCA2 …

Abstract BACKGROUND: For BRCA1/BRCA2 gene testing to benefit public health, mutation
carriers must initiate appropriate risk management strategies. There has been little research …

Please cite this paper as: Manchanda R, Abdelraheim A, Johnson M, Rosenthal A, Benjamin
E, Brunell C, Burnell M, Side L, Gessler S, Saridogan E, Oram D, Jacobs I, Menon U …

Purpose: The uptake of risk-reducing surgery in women at increased risk of breast and
ovarian cancer is highly variable between countries and centers within countries. We have …

Despite the quickening momentum of genomic discovery, the communication, behavioral,
and social sciences research needed for translating this discovery into public health …

Skytte A‐B, Gerdes A‐M, Andersen MK, Sunde L, Brøndum‐Nielsen K, Waldstrøm M,
Kølvraa S, Crüger D. Risk‐reducing mastectomy and salpingo‐oophorectomy in unaffected …