Purpose: Genomic alterations (including gene hypermethylation) are likely to precede the
phenotypic changes associated with breast tumorigenesis. From a prospective collection of …

Objective: The aim of this study was to identify the unmet information needs of healthcare
professionals managing risk-reducing bilateral salpingo-oophorectomy (RRBSO) in …

With the expansion of genomic-based clinical applications, it is important to consider the
potential impact of this information particularly in terms of how it may be interpreted and …

Breast cancer is the second most common cancer among women and the second leading
cause of cancer death in the US. In 2006, more than 214,000 new breast cancer cases were …

Five to 10% of all breast cancer cases are due to mutations of high penetrance susceptibility
genes, especially BRCA1 and BRCA2. In families with known BRCA mutations, disclosure of …

Objectives Effective chemoprevention strategies exist for women at high risk for breast
cancer, yet uptake is low. Physician recommendation is an important determinant of uptake …

In the past 10 years our knowledge of hereditary breast cancer, and specifically the breast
cancer susceptibility genes BRCA1 and BRCA2, has dramatically increased, as has our …

In the last 15 years, our understanding of genes that predispose to breast cancer has
increased enormously. Germline alleles have been identified that have a modest effect on …

With the rising number of individuals affected with diabetes and the significant health care
costs of treatment, the emphasis on prevention is key to controlling the health burden of this …

Professional organizations provide surveillance guidelines for BRCA1 and BRCA2 (BRCA)
carriers with intact breasts and/or ovaries to facilitate early cancer detection. However …