Ethnopharmacological relevance With high mortality and morbidity rates, lung cancer (LC)
has become one of the major threats to human health. The treatment strategies for LC …

The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median
survival of less than 15 months. However, clinical strategies and effective therapies are …

Simple Summary Despite an initial response to therapy, many lung cancer patients
inevitably develop resistance to therapy leading to decreased duration of response and …

Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer, accounting for
approximately 15% among all lung cancers. Despite the ability of chemotherapy, the first …

Lung cancer is the most common cancer and the leading cause of cancer-related death
worldwide. However, mechanisms of its progression remained unclear and new treatments …

Bioisosterism is one of the leading strategies in medicinal chemistry for the design and
modification of drugs, consisting in replacing an atom or a substituent with a different atom or …

In small cell lung cancer (SCLC), acquired resistance to DNA-damaging therapy is
challenging to study because rebiopsy is rarely performed. We used patient-derived …

Background Colon adenocarcinoma (COAD) is a common digestive system malignancy with
high mortality and poor prognosis. Accumulating evidence indicates that choline metabolism …

Small cell lung carcinoma (SCLC) is characterized by high metastatic rate and poor
prognosis. The platinum-based chemotherapy still represents the backbone of the therapy; …