In this review, the clinical features of Parkinson's disease, both motor and non‐motor, are
described in the context of the progression of the disease. Also briefly discussed are the …

Parkinson disease (PD) is a neurodegenerative disorder characterized by progressive motor
and nonmotor impairments. These impairments incline many patients towards a sedentary …

BACKGROUND: Neuropsychiatric symptoms are common complaints of elderly persons.
Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of …

Impaired sleep and alertness, initially recognized by James Parkinson in his famous
monograph “An Essay on the Shaking Palsy” in 1817, is one of the most common and …

Sleep disorders constitute major nonmotor features of Parkinson's disease (PD) that have a
substantial effect on patients' quality of life and can be related to the progression of the …

Background: The 24‐week, double‐blind Efficacy and Safety Evaluation in PD–Adjunct
(EASE‐PD Adjunct) study randomized patients with advanced Parkinson's disease (PD) …

More than 1 million people in the United States have Parkinson disease (PD), more than are
diagnosed as having multiple sclerosis, amyotrophic lateral sclerosis, muscular dystrophy …

Though l-3, 4-dihydroxyphenylalanine (L-DOPA) is universally employed for alleviation of
motor dysfunction in Parkinson's disease (PD), it is poorly-effective against co-morbid …

Background DLG2, also known as postsynaptic density protein-93 (PSD-93) or chapsyn-
110, is an excitatory postsynaptic scaffolding protein that interacts with synaptic surface …

BACKGROUND: Sleep disorders (SD) are one of the most frequent non-motor
manifestations of Parkinson's disease (PD). Recent studies showed that SD may precede …