Neuropathic pain (NP) is pain caused by damage to the somatosensory system. It is a
common progressive neurodegenerative disease that usually presents with clinical features …

Colorectal cancer (CRC) is the third most common malignant tumor in the world. CRC has
high morbidity and mortality rates and it is a serious threat to human health. Ferroptosis is a …

To develop next-generation metal drugs with high efficiency and low toxicity for targeting
inhibition of gastric tumor growth and metastasis, we not only optimized a series of …

Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell
death, which can be triggered by caspase-3 activation upon stimulation. Silenced GSDME …

Ferroptosis is an emerging novel form of non-apoptotic, regulated cell death that is heavily
dependent on iron and characterized by rupture in plasma membrane. Ferroptosis is distinct …

Patients with advanced-stage or treatment-resistant colorectal cancer (CRC) benefit less
from traditional therapies; hence, new therapeutic strategies may help improve the treatment …

Gastrointestinal cancer is a significant global health burden, necessitating the development
of novel therapeutic strategies. Emerging evidence has highlighted the potential of targeting …

Introduction Pancreatic ductal adenocarcinoma (PDAC) has the highest mortality rate
among all solid tumors. Tumorigenesis is promoted by the oncogene KRAS, and KRAS …

Triple negative breast carcinoma (TNBC) accounts for 15–20% of all incident breast cancers
(BC) and is known to be highly invasive, has fewer treatment options, and tends to have a …

Programmed cell death (PCD) induction is a promising strategy for killing gastric cancer
cells. In this study, we investigated the effects of chrysophanol on apoptosis and ferroptosis …