Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

Oxidative stress has been proposed as a key contributor to lifestyle-and age-related
diseases. Because free radicals play an important role in various processes such as …

Aging contributes to the progressive loss of cellular biological functions and increases the
risk of age-related diseases. Cardiovascular diseases, some neurological disorders and …

Aging is usually considered a key risk factor associated with multiple diseases, such as
neurodegenerative diseases, cardiovascular diseases and cancer. Furthermore, the burden …

Abstract Cholestane-3β, 5α, 6β-triol (CT) is a primary metabolite of 5, 6-epoxycholesterols
(5, 6-EC) that is catalyzed by the cholesterol-5, 6-epoxide hydrolase (ChEH). CT is a well …

Graphical abstract Abstract 7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol
essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the …

Aging is a complex biological process which can be associated with skeletal muscle
degradation leading to sarcopenia. The aim of this study consisted i) to determine the …

Ultra-processed foods (UPFs) have gained substantial attention in the scientific community
due to their surging consumption and potential health repercussions. In addition to their well …

Abstract Oncosterone (6-oxo-cholestane-3β, 5α-diol; OCDO) is an oncometabolite and a
tumor promoter on estrogen receptor alpha-positive breast cancer (ER (+) BC) and triple …

The pathogenesis of age-related macular degeneration (AMD), a degenerative retinopathy,
remains unclear. Administration of anti-vascular endothelial growth factor agents …