Unravelling cell migration: defining movement from the cell surface

F Merino-Casallo, MJ Gomez-Benito… - Cell adhesion & …, 2022 - Taylor & Francis
Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

[HTML][HTML] Filopodia in vitro and in vivo

TCA Blake, JL Gallop - Annual Review of Cell and …, 2023 - annualreviews.org
Filopodia are dynamic cell surface protrusions used for cell motility, pathogen infection, and
tissue development. The molecular mechanisms determining how and where filopodia grow …

[HTML][HTML] Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins

FE Fregoso, M Boczkowska, G Rebowski… - Nature …, 2023 - nature.com
Cortactin coactivates Arp2/3 complex synergistically with WASP-family nucleation-promoting
factors (NPFs) and stabilizes branched networks by linking Arp2/3 complex to F-actin. It is …

A versatile cortical pattern-forming circuit based on Rho, F-actin, Ect2, and RGA-3/4

A Michaud, M Leda, ZT Swider, S Kim, J He… - Journal of Cell …, 2022 - rupress.org
Many cells can generate complementary traveling waves of actin filaments (F-actin) and
cytoskeletal regulators. This phenomenon, termed cortical excitability, results from coupled …

Cellular sentience as the primary source of biological order and evolution

F Baluška, AS Reber, WB Miller Jr - Biosystems, 2022 - Elsevier
All life is cellular, starting some 4 billion years ago with the emergence of the first cells. In
order to survive their early evolution in the face of an extremely challenging environment, the …

Evolutionary tuning of barbed end competition allows simultaneous construction of architecturally distinct actin structures

ACE Wirshing, SG Rodriguez, BL Goode - Journal of Cell Biology, 2023 - rupress.org
How cells simultaneously assemble actin structures of distinct sizes, shapes, and
filamentous architectures is still not well understood. Here, we used budding yeast as a …

[HTML][HTML] Cytosolic concentrations of actin binding proteins and the implications for in vivo F-actin turnover

S Gonzalez Rodriguez, ACE Wirshing… - Journal of Cell …, 2023 - rupress.org
Understanding how numerous actin-binding proteins (ABPs) work in concert to control the
assembly, organization, and turnover of the actin cytoskeleton requires quantitative …

[HTML][HTML] MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics

S Rajan, JR Terman, E Reisler - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Actin and its dynamic structural remodelings are involved in multiple cellular functions,
including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle …

[HTML][HTML] Novel Au carbene complexes as promising multi-target agents in breast cancer treatment

J Ceramella, A Mariconda, M Sirignano, D Iacopetta… - Pharmaceuticals, 2022 - mdpi.com
Over the past decade, metal complexes based on N-heterocyclic carbenes (NHCs) have
attracted great attention due to their wide and exciting applications in material sciences and …

[HTML][HTML] Role of actin-binding proteins in the regulation of cellular mechanics

AV Vakhrusheva, AV Murashko, ES Trifonova… - European Journal of …, 2022 - Elsevier
The viscoelastic parameters of the cell can report on the cell state, cellular processes and
diseases. Cell mechanics strongly rely on the properties of the cytoskeleton, an important …