There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …

Metastatic disease is responsible for approximately 90% of cancer deaths. For successful
dissemination and metastasis, cancer cells must evade detection and destruction by the …

Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …

Osteoarthritis (OA) is the most common chronic disease of human joints. The basis of
pathologic changes involves all the tissues forming the joint; already, at an early stage, it has …

The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …

Members of the tumour necrosis factor (TNF) receptor superfamily have important functions
in immunity and inflammation. Recently linear ubiquitin chains assembled by a complex …

Chronic inflammatory mediators exert pleiotropic effects in the development of cancer. On
the one hand, inflammation favors carcinogenesis, malignant transformation, tumor growth …

Polyubiquitin (pUb) chains formed between the C terminus of ubiquitin and lysine 63 (K63)
or methionine 1 (M1) of another ubiquitin have been implicated in the activation of the …

The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

Inflammation is usually analysed from the perspective of tissue-infiltrating leukocytes.
Microvascular endothelial cells at a site of inflammation are both active participants in and …